The 5'-3' exoribonuclease Pacman (Xrn1) regulates expression of the heat shock protein Hsp67Bc and the microRNA miR-277-3p in Drosophila wing imaginal discs [PDF]
, 2013 Pacman/Xrn1 is a highly conserved exoribonuclease known to play a critical role in gene regulatory events such as control of mRNA stability, RNA interference and regulation via miRNAs.
Bate M +7 more
core +1 more source
BMC Genomics, 2018 Background Exoribonucleases are crucial for RNA degradation in Escherichia coli but the roles of RNase R and PNPase and their potential overlap in stationary phase are not well characterized.
Clémentine Dressaire +5 more
doaj +1 more source
Multispecies reconstructions uncover widespread conservation, and lineage-specific elaborations in eukaryotic mRNA metabolism. [PDF]
, 2018 The degree of conservation and evolution of cytoplasmic mRNA metabolism pathways across the eukaryotes remains incompletely resolved. In this study, we describe a comprehensive genome and transcriptome-wide analysis of proteins involved in mRNA ...
Bannerman, Bridget P +3 more
core +2 more sources
RNase J1 and J2 Are Host-Encoded Factors for Plasmid Replication
Frontiers in Microbiology, 2021 Plasmids need to ensure their transmission to both daughter-cells when their host divides, but should at the same time avoid overtaxing their hosts by directing excessive host-resources toward production of plasmid factors.
Vanessa Andrade Guimarães +10 more
doaj +1 more source
3'-Phosphoadenosine 5'-Phosphate Accumulation Delays the Circadian System. [PDF]
, 2018 The circadian system optimizes cellular responses to stress, but the signaling pathways that convey the metabolic consequences of stress into this molecular timekeeping mechanism remain unclear.
Chan, Kai Xun +2 more
core +3 more sources
Cell Reports, 2019 Summary: Cell-based studies of human ribonucleases traditionally rely on methods that deplete proteins slowly. We engineered cells in which the 3′→5′ exoribonucleases of the exosome complex, DIS3 and EXOSC10, can be rapidly eliminated to assess their ...
Lee Davidson +7 more
doaj +1 more source
PLoS ONE, 2018 Flaviviruses accumulate abundant subgenomic RNA (sfRNA) in infected cells. It has been reported that sfRNA results from stalling of host 5'-to-3' exoribonuclease XRN1 at the highly structured RNA of the 3' untranslated region (UTR).
Yi-Shiuan Chen +4 more
doaj +1 more source
Biochemical Characterization of Exoribonuclease Encoded by SARS Coronavirus [PDF]
BMB Reports, 2007 The nsp14 protein is an exoribonuclease that is encoded by severe acute respiratory syndrome coronavirus (SARS-CoV). We have cloned and expressed the nsp14 protein in Escherichia coli, and characterized the nature and the role(s) of the metal ions in the reaction chemistry.
Ping, Chen +5 more
openaire +2 more sources
RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1 [PDF]
, 2015 Ribonucleases are critically important in many cellular and developmental processes and defects in their expression are associated with human disease.
Amy L. Pashler +5 more
core +1 more source
Characterization of a bafinivirus exoribonuclease activity
Journal of General Virology, 2018 White bream virus (WBV), a poorly characterized plus-strand RNA virus infecting freshwater fish of the Cyprinidae family, is the prototype species of the genus Bafinivirus in the subfamily Torovirinae (family Coronaviridae, order Nidovirales). In common with other nidoviruses featuring >20 kilobase genomes, bafiniviruses have been predicted to encode ...
Izabela, Durzynska +4 more
openaire +2 more sources