Results 51 to 60 of about 13,181 (183)

Gene cloning and characteristics of the RND-type multidrug efflux pump MuxABC-OpmB possessing two RND components in Pseudomonas aeruginosa [PDF]

Microbiology, 2009
muxA-muxB-muxC-opmB (formerly PA2528-PA2527-PA2526-opmB), encoding a putative resistance nodulation cell division (RND)-type multidrug efflux pump system, was cloned from Pseudomonas aeruginosa PAO1. Introduction of muxABC-opmB into P.
Takehiko, Mima, Naoki, Kohira, Yang, Li, Hiroshi, Sekiya, Wakano, Ogawa, Teruo, Kuroda, Tomofusa, Tsuchiya   +6 more
openaire   +2 more sources

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Innovation Pathways to Carbon Efficiency: Disentangling the Effects of AI, R&D, and Clean Energy Blessings on U.S. Environmental Sustainability

Business Strategy and the Environment, EarlyView.
ABSTRACT The United States (U.S.) faces challenges in achieving its ambitious net‐zero carbon emissions target by 2050, with current emissions having fallen by less than 1% in 2024. Despite an investment of $500 billion in low‐carbon resources while holding the second‐largest green technology patent portfolio globally, it is further imperative to ...
Md Zubair Ahmad, Jewel Rana, Mohammad Fakhrul Islam, Md Nazmul Islam Jihad, Md. Rashed, Md. Kamal Uddin   +5 more
wiley   +1 more source

Pilot randomized controlled trial evaluating the effect of random nicotine delivery on cigarettes per day and smoke exposure

Brain Research Bulletin, 2022
Background: Many smokers report attempting to quit each year, yet most relapse, in part due to exposure to smoking-related cues. It is hypothesized that extinction of the cue-drug association could be facilitated through random nicotine delivery (RND ...
Jessica M. Yingst, Courtney Lester, Craig Livelsberger, Sophia I. Allen, Erin Hammett, Susan Veldheer, Breianna Hummer, Candace Bordner, Junjia Zhu, Christopher N. Sciamanna, Neil Trushin, Hock S. Tan, Stephen J. Wilson, Robert C. Twining, Jonathan Foulds, Patricia Sue Grigson   +15 more
doaj   +1 more source

Instability mechanism and failure characteristics of underground cavern in block system under the action of seismic waves

Deep Underground Science and Engineering, EarlyView.
Seismic waves with tensile stress, high amplitude, and low frequency are most likely to trigger block instability and sliding. Blocks with a single sliding surface are more prone to movement than those with multiple constraints, and roof‐positioned blocks are especially vulnerable to slide.
Xiao Wang, Jinxiao Liu, Gaoshuo Zhang, Wenxin Li, Changdi He   +4 more
wiley   +1 more source

Resistance-Nodulation-Division Multidrug Efflux Pumps in Gram-Negative Bacteria: Role in Virulence

Antibiotics, 2013
Resistance-Nodulation-Division (RND) efflux pumps are one of the most important determinants of multidrug resistance (MDR) in Gram-negative bacteria. With an ever increasing number of Gram-negative clinical isolates exhibiting MDR phenotypes as a result ...
Ayush Kumar, Dinesh M. Fernando
doaj   +1 more source

A first in disease trial of the safety, tolerability, and anti‐seizure effects of ES‐481 in drug‐resistant epilepsy

Epilepsia Open, EarlyView.
Abstract Objectives ES‐481 is a novel potent and selective antagonist of TARP‐y8‐dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES‐481 as an add‐on anti‐seizure medication (ASM) in adults with drug‐resistant epilepsy (DRE). Methods This was a Phase 2A double‐blind,
Emma C. Foster, Lyn Millist, Jack Germaine, Stephanie Chamorro, Caitlin Roberts, John‐Paul Nicolo, Sean Hosking, Piero Perucca, Saul Mullen, Heather Robinson, Rebecca Wharrie, Brittany Walsh, David Reutens, Kimberley Irwin, Hao Zeng, Robert Niecestro, Terence J. O'Brien   +16 more
wiley   +1 more source

Repairing the Microsoft BASIC RND function [PDF]

Behavior Research Methods, Instruments, & Computers, 1988
Difficulties with the Microsoft BASIC function for generating random numbers (RND) are cited and new problems reported. Fixes are suggested that allow use of some of the speed of the original function and that produce greatly improved pseudorandom numbers. A published generator is combined with the RND function as a compromise solution.
openaire   +1 more source

TORQUE MEASURING CHANNELS: DYNAMIC AND STATIC METROLOGICAL CHARACTERISTICS

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska, 2020
A formalized method for obtaining the analytical dependencies for the evaluation of the main dynamic and static metrological characteristics of a torque measuring channel with a capacitance sensor operating under the regulation of a microcontroller is ...
Vasyl Kukharchuk, Valerii Hraniak, Samoil Katsyv, Volodymyr Holodyuk   +3 more
doaj   +1 more source

Case Report: Progressive disease of BRCA2-mutant colon adenocarcinoma following talazoparib therapy

Frontiers in Oncology, 2023
Colorectal cancer (CRC) is currently one of the most common tumor types diagnosed worldwide. In the early stages, the disease responds well to surgical and chemotherapeutic treatment, but in the later stages when therapeutic options are exhausted ...
Elizaveta Polyanskaya, Alexandra Lebedeva, Olesya Kuznetsova, Olesya Kuznetsova, Ekaterina Belova, Ekaterina Belova, Alexandra Kavun, Maxim Ivanov, Maxim Ivanov, Mikhail Fedyanin, Mikhail Fedyanin, Mikhail Fedyanin, Alexey Tryakin, Vladislav Mileyko, Dmitry Nosov   +14 more
doaj   +1 more source