Results 41 to 50 of about 23,184 (200)

The ins and outs of RND efflux pumps in Escherichia coli [PDF]

Frontiers in Microbiology, 2015
Infectious diseases remain one of the principal causes of morbidity and mortality in the world. Relevant authorities including the WHO and CDC have expressed serious concern regarding the continued increase in the development of multidrug resistance among bacteria.
Anes, Joao; McCusker, Matthew P.; Fanning, Seamus; Martins, Marta   +4 more
openaire   +3 more sources

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance

BMC Microbiology, 2009
Background Burkholderia cenocepacia are opportunistic Gram-negative bacteria that can cause chronic pulmonary infections in patients with cystic fibrosis.
Venturi Vittorio, Bertani Iris, Milano Anna, Bazzini Silvia, Flannagan Ronald S, Pasca Maria R, Buroni Silvia, Valvano Miguel A, Riccardi Giovanna   +8 more
doaj   +1 more source

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins [PDF]

, 2013
Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol.
Riou, P, Parker, Peter J., O’Reilly, N., George, Roger, Ritu Garg, McColl, Brad, Ganka Bineva, Kjær, S., Svend Kjær, Garg, R, Bineva, G., Thompson, AJ, Reymond, N, Thompson, Andrew J., Philippe Riou, Purkiss, Andrew, Nicola O’Reilly, Parker, Peter J, Brad McColl, Peter J. Parker, Neil Q. McDonald, Parker, Peter J.; id_orcid, O’Reilly, Nicola, Riou, P., Purkiss, A, Parker, PJ, Thompson, A.J., McColl, B, Cain, RJ, Parker, P.J., Kjær, Svend, McColl, B., Andrew Purkiss, O’Reilly, N, Kjær, S, Garg, R., Garg, Ritu, O'Reilly, Nicola, Anne J. Ridley, Cain, Robert J, Robert J. Cain, McDonald, Neil Q, Ridley, Anne J, Bineva, G, Ridley, A.J., Purkiss, Andrew G., Nicolas Reymond, George, R., Thompson, Andrew J, Reymond, N., Reymond, Nicolas, Cain, Robert J., Bineva, Ganka, McDonald, NQ, Riou, Philippe, Andrew J. Thompson, Ridley, AJ, Kjaer, Svend, George, R, Cain, R.J., Ridley, Anne J., Roger George, McDonald, Neil Q.   +62 more
core   +1 more source

Rnd Proteins Function as RhoA Antagonists by Activating p190 RhoGAP [PDF]

, 2003
Background: The Rnd proteins Rnd1, Rnd2, and Rnd3 (RhoE) comprise a unique branch of Rho-family G-proteins that lack intrinsic GTPase activity and consequently remain constitutively “active.” Prior studies have suggested that Rnd proteins play pivotal ...
Wennerberg, Krister, Der, Channing J, Ellerbroek, Shawn M, Forget, Marie-Annick, Arthur, William T, Settleman, Jeffrey, Hansen, Steen H, Burridge, Keith   +7 more
core   +1 more source

Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump

Microbiology Spectrum, 2022
Bacterial efflux pumps in the resistance-nodulation-cell division (RND) family of Gram-negative bacteria contribute significantly to the development of antimicrobial resistance by many pathogens. In this study, we selected the MtrD transporter protein of
Meinan Lyu, Julio C. Ayala, Isabella Chirakos, Chih-Chia Su, William M. Shafer, Edward W. Yu   +5 more
doaj   +1 more source

Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins. [PDF]

PLoS ONE, 2017
The Rnd family of proteins, Rnd1, Rnd2 and Rnd3, are atypical Rho family GTPases, which bind to but do not hydrolyse GTP. They interact with plexins, which are receptors for semaphorins, and are hypothesised to regulate plexin signalling.
Thomas Wylie, Ritu Garg, Anne J Ridley, Maria R Conte   +3 more
doaj   +1 more source

Defining the RND-binding residues of AcrA

Access Microbiology, 2020
The resistance-nodulation-division (RND) family of efflux pumps confer clinically relevant antibiotic resistance in Gram-negative bacteria, such as Salmonella enterica. RND pumps, including AcrB, are organized as tri-partite systems, consisting of an inner membrane RND pump, a periplasmic adaptor protein (PAP) and an outer membrane channel. Previously,
Ilyas Alav, Ricardo Torres, Vassiliy Bavro, Jessica Blair   +3 more
openaire   +1 more source

Evolution of RND efflux pumps in the development of a successful pathogen

Drug Resistance Updates, 2023
This study examined the origins and evolution of the AdeABC, AdeFGH and AdeIJK efflux pumps in the Acinetobacter genus, including human and animal pathogens and species from non-clinical environments.Comparative genome analyses were performed using the reference sequences for 70 Acinetobacter species to identify putative orthologs of AdeABC, AdeFGH and
Naidu, Varsha, Bartczak, Amelia, Brzoska, Anthony J., Lewis, Peter, Eijkelkamp, Bart A., Paulsen, Ian T., Elbourne, Liam D. H., Hassan, Karl A.   +7 more
openaire   +3 more sources

Beyond antibiotic resistance: evidence for resistance-nodulation-division (RND) efflux pumps as virulence determinants [PDF]

Microbiology and Molecular Biology Reviews
Ilyas Alav, Corrella Detweiler
exaly   +2 more sources

„Können nicht warten, bis neue Pandemie entsteht“: Deutscher Tierseuchenexperte leitet UN-Gremium zur Pandemieprävention

, 2021
Corona war kein Einzelfall: Drei Viertel aller neu auftretenden Infektionskrankheiten sind laut WHO von Tieren auf Menschen übergesprungen. Um das in Zukunft besser verhindern zu können, arbeitet ein interdisziplinärer Expertenrat nun an einem globalen ...
RND/dpa
core