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mBio, 2017 Resistance-nodulation-division (RND) superfamily efflux systems have been widely studied for their role in antibiotic resistance, but their native biological functions remain poorly understood.
Dillon E. Kunkle +2 more
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Structural studies of bacterial RND-transporters [PDF]
, 2008 Even though transporters that extrude toxic compounds are found in all types of cells, they vary in the chemical diversity of their transported substrates, in their molecular architecture and in their energization source. In Gram-negative bacteria, drug transporters belonging to the resistance-nodulation-cell division (RND) family of proteins are ...
Sennhauser, Gaby
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MOLECULAR DYNAMICS COMPUTER SIMULATIONS OF MULTIDRUG RND EFFLUX PUMPS [PDF]
Computational and Structural Biotechnology Journal, 2013 Over-expression of multidrug efflux pumps of the Resistance Nodulation Division (RND) protein super family counts among the main causes for microbial resistance against pharmaceuticals. Understanding the molecular basis of this process is one of the major challenges of modern biomedical research, involving a broad range of experimental and ...
RUGGERONE, PAOLO +4 more
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Diversity and conservation of RND efflux pumps across Escherichia coli [PDF]
, 2022 RND efflux pumps are located in the inner membrane of Gram-negative bacteria and form tripartite complexes that span the inner membrane, periplasm and outer membrane. It is widely accepted that Escherichia coli isolates possess six RND pumps; AcrB, AcrD,
Pugh, Hannah
core +6 more sources
Pathophysiological functions of Rnd proteins [PDF]
Small GTPases, 2020 Rnd proteins constitute a subfamily of Rho GTPases represented in mammals by Rnd1, Rnd2 and Rnd3. Despite their GTPase structure, their specific feature is the inability to hydrolyse GTP-bound nucleotide. This aspect makes them atypical among Rho GTPases.
Basbous, Sara +3 more
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Scientific Reports, 2021 Sequence variants (SV) in protein bio therapeutics can be categorized as unwanted impurities and may raise serious concerns in efficacy and safety of the product.
Anushikha Thakur +11 more
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Mechanisms of RND multidrug efflux pumps [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009 RND (Resistance-Nodulation-Division) family transporters are widespread especially among Gram-negative bacteria, and catalyze the active efflux of many antibiotics and chemotherapeutic agents. They have very large periplasmic domains, and form tripartite complexes with outer membrane channels and periplasmic adaptor proteins.
Hiroshi, Nikaido, Yumiko, Takatsuka
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How resistance-nodulation-division (RND) efflux pumps contribute to virulence. [PDF]
PLoS PathogIn Gram-negative bacteria, multi-subunit efflux pumps transport molecules across the inner membrane, periplasm, and outer membrane to the extracellular environment.
Detweiler CS, Alav I.
europepmc +2 more sources
RND multidrug efflux pumps: what are they good for? [PDF]
Frontiers in Microbiology, 2013 Multidrug efflux pumps are chromosomally encoded genetic elements capable of mediating resistance to toxic compounds in several life forms. In bacteria, these elements are involved in intrinsic and acquired resistance to antibiotics. Unlike other well-known horizontally acquired antibiotic resistance determinants, genes encoding for multidrug efflux ...
Alvarez-Ortega, Carolina +2 more
openaire +5 more sources
Vibrio cholerae VexH encodes a multiple drug efflux pump that contributes to the production of cholera toxin and the toxin co-regulated pilus. [PDF]
PLoS ONE, 2012 The resistance-nodulation-division (RND) efflux systems are ubiquitous transporters that function in antimicrobial resistance. Recent studies showed that RND systems were required for virulence factor production in Vibrio cholerae. The V. cholerae genome
Dawn L Taylor +2 more
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