Cryo-EM reveals the structural heterogeneity and conformational flexibility of multidrug efflux pumps MdtB and MdtF [PDF]
mBioResistance-nodulation-cell division (RND) efflux pumps are the major cause of multidrug resistance in bacteria, particularly in Gram-negative bacteria. They are complex molecular machines forming tripartite assemblies that actively transport out a wide ...
Surekha Padmanaban +3 more
doaj +2 more sources
Antigenicity analysis of the recombinant fusion proteins NlpI of Mannheimia haemolytica and DsbA of Pasteurella multocida [PDF]
BMC Veterinary ResearchTo analyze the antigenic characteristics of the recombinant fusion proteins rNlpI-DsbA (rND) of bovine Mannheimia haemolytica and Pasteurella multocida, respectively, and lay a foundation for the development of bivalent subunit vaccine development.
Shuyun Xu +11 more
doaj +2 more sources
Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens
Antibiotics, 2021 Drug resistance represents a great concern among people with cystic fibrosis (CF), due to the recurrent and prolonged antibiotic therapy they should often undergo.
Viola Camilla Scoffone +2 more
exaly +3 more sources
Acute effect of continuous perturbations of the base of support on reactive balance response [PDF]
Scientific ReportsUnexpected perturbations (UP) of the support base challenge balance control and require effective reactive postural mechanisms. Continuous perturbations (CPs) of the base of support also affect postural stability but their influence on reactive postural ...
A. Rizzato +7 more
doaj +2 more sources
How resistance-nodulation-division (RND) efflux pumps contribute to virulence. [PDF]
PLoS PathogensIn Gram-negative bacteria, multi-subunit efflux pumps transport molecules across the inner membrane, periplasm, and outer membrane to the extracellular environment.
Corrella S Detweiler, Ilyas Alav
doaj +2 more sources
Inhibition of RND-mediated efflux attenuates antibiotic resistance and virulence in hypervirulent Klebsiella pneumoniae [PDF]
Infection and ImmunityKlebsiella pneumoniae (Kp) is a major human pathogen causing hospital-acquired and community-acquired infections with emerging hypervirulent strains (hvKp) posing a significant threat due to its ability to cause severe invasive infections in healthy ...
Mia E. Van Allen +3 more
doaj +2 more sources
Sleep moderates how prenatal and childhood pollutant exposure impacts white matter microstructural integrity in adolescence [PDF]
npj Biological Timing and SleepAir pollution is a ubiquitous neurotoxicant linked to altered structural brain connectivity. Sleep may offer neuroprotection through its roles in brain waste clearance and immune regulation.
Devyn L. Cotter +7 more
doaj +2 more sources
IEEE Journal of the Electron Devices Society, 2021 High Temperature Reverse Bias (HTRB) reliability failure is found to be caused by huge amount of undesirable hydrogen proton (H+) ions from packaging resin or external environment, while Temperature Humidity Bias (THB) reliability failure is known
Ai Loon Ooi, David Goh, Voon Cheng Ngwan
doaj +1 more source
Fondatia : Jurnal Pendidikan Dasar, 2022 Learning media are learning aids that can be physical or non-physical to convey messages from teachers to students. The purpose of this study is to determine the effectiveness of the use and process of product development in the form of Montessori-based ...
Aisah Nur Fitri +2 more
doaj +1 more source
Design of clock and data recovery system’s behavioral model for high speed transceivers of serial interfaces [PDF]
ITM Web of Conferences, 2019 This paper provides a parameterizable behavioral model of a clock and data recovery system (CDR) based on phase-locked loop (PLL) for the receiver part of a high-speed serial interfaces.
Dubinskiy Alexey V. +2 more
doaj +1 more source