Results 101 to 110 of about 4,722,044 (303)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Road User Interactions: Patterns of Road Use and Perception of Driving Risk [PDF]

open access: yes, 2002
The goal of the Road User Interactions research programme is a better understanding of the human factors of our road transport system: road user demographics, risk perceptions of road users, and the driving attitudes of various road user groups.
Baas, Peter H., Charlton, Samuel G.
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Survey of free speeds on roads outside built-up areas with elevated speed limits in Hungary [PDF]

open access: yes, 2013
In Hungary since 2008 some roads operate with posted speed limits which are higher than the general 90 kmph outside urban areas. The goal of the current study was to explore how well road users can recognize various types of roads.
Ivan, Gabriella, Koren, Csaba
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Leading the Worldwide Movement to Improve Road Safety [PDF]

open access: yes, 2013
Bloomberg Philanthropies' $125 million, five-year Global Road Safety program is aimed at reducing preventable road traffic deaths and injuries in ten countries through initiatives including increased seat-belt and helmet usage, reduced speed limits ...

core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

A Grotian Tradition of Theory and Practice: Grotius, Law, and Moral Skepticism in the Thought of Hedley Bull [PDF]

open access: yes, 1997
This paper describes a system that incrementally constructs an increasingly accurate road map from GPS traces from a single vehicle. The resulting road map contains information about the road such as road gradient which can be used by functions in a ...
Kingsbury, Benedict
core   +1 more source

Modelling Planner-Carrier Interactions in Road Freight Transport: Optimization of Road Maintenance Costs Via Overloading Control

open access: yes, 2013
A bi-level modelling approach is proposed to represent the interaction between the vehicle loading practices of road freight transport carriers, and the decisions of a road planning authority responsible both for road maintenance and for the enforcement ...
Fowkes, AS, Moreno, E, Watling, DP
core   +1 more source

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