Results 91 to 100 of about 1,777,837 (318)
Community Attitudes to Road Safety, 1995
, 2019 The survey is the eighth in a series of national studies conducted since October 1986 for the Federal Office of Road Safety, designed to monitor key community attitudes toward road safety issues.
Adams, Kathryn +2 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 2015 Every driver will have experienced the situation in which, as additional traffic joins a road, speeds fall, queues form and travel times become longer and more predictable. Engineers and traffic scientists have devoted considerable effort to understanding how such conditions arise, and how the key parameters of traffic flow, traffic concentration (or ...
May, A, Liu, R, Shepherd, S
openaire +2 more sources
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Evaluation of the Effect of Project Management Techniques on Road Construction Projects in Nigeria [PDF]
European Project Management Journal, 2017 Project management is an innovative management practice that tends to achieve stated or specified objectives within specific time and budget limits through optimum use of resources. The aim of the study was to investigate the effect of project management
Onifade Morakinyo Kehinde +2 more
doaj
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
High-Road and Low-Road Programs.
AI Mag., 1981 Consider a class of computing problem for which all sufficiently short programs are too slow and sufficiently fast programs are too large. Most non-standard problems of this kind were strictly alone for the first twenty-years or so of the computing era. There were two good reasons.
openaire +3 more sources
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source