Results 91 to 100 of about 4,722,044 (303)
Child–parent interaction in relation to road safety education : Part 2 – main report [PDF]
, 2008 • Children and young people are particularly vulnerable road users. • Child pedestrian injury rates are poor compared with the rest of Europe. • The factors that impact on children’s road safety and their capability in traffic are numerous, multi-faceted
Ayrton, Rebecca +6 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
The Challenges and Obstacles of Post-Disaster Road Infrastructure Reconstruction in the Pre-Construction Phase [PDF]
, 2015 Purpose The reconstruction of road infrastructure in the post-disaster context require different approach when compared with road projects in the normal development context.
Amaratunga, Dilanthi +2 more
core +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Evaluation of the Effect of Project Management Techniques on Road Construction Projects in Nigeria [PDF]
European Project Management Journal, 2017 Project management is an innovative management practice that tends to achieve stated or specified objectives within specific time and budget limits through optimum use of resources. The aim of the study was to investigate the effect of project management
Onifade Morakinyo Kehinde +2 more
doaj
Pedestrian Amenity: On Street Survey Design [PDF]
, 1987 Any new road, road improvement or traffic management scheme could affect pedestrian journeys in its locality or elsewhere. Some journeys may be affected directly, with severance caused where the new road or road improvement cuts across a pedestrian ...
Hopkinson, P.G., May, A.D., Turvey, I.G.
core
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
The Influence of Town Centre Conditions on Pedestrian Trip Behaviour: Results from a Household Survey in Two Locations [PDF]
, 1987 1.1.1 Any new road, road improvement or traffic management scheme could affect pedestrian journeys in its locality or elsewhere. Some journeys may be affected directly, with severance caused where the new road or road improvement cuts across a ...
Hopkinson, P.G., May, A.D., Turvey, I.G.
core
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source