Results 71 to 80 of about 1,777,837 (318)

Assessment of Road Rehabilitation in Ibadan, Nigeria

open access: yesIndonesian Journal of Geography, 2020
The study examined road rehabilitation in Ibadan North East Local Government of Oyo State, Nigeria. The data used in this study was obtained from both primary and secondary sources.
Adewale Yoade   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Road Accident Data, 1996

open access: yes, 1998
copyright UK Data Service and data collection copyright owner.Road accident statistics are collected from information about personal injury road accidents and their consequent casualties, to a common national standard.
Department of Transport, Road Accident Statistics Branch
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Operating speed as a key factor in studying the driver behaviour in a rural context

open access: yesTransport, 2016
The research aims to explore the effects of geometric road features on driver speed behaviour in order to identify unsafe road segments where high reductions in speed between successive road elements occur.
Francesca Russo   +2 more
doaj   +1 more source

Community Attitudes to Road Safety, 1996

open access: yes, 2019
The survey is the ninth in a series of national studies conducted since October 1986 for the Federal Office of Road Safety, designed to monitor key community attitudes toward road safety issues.
Adams, Kathryn   +2 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

A functional road classification with data mining techniques

open access: yesTransport, 2014
The current international road standards, in order to give organization and safety, promote the classification of roads according to their technical and functional characteristics beyond their administrative membership, but the procedures are yet ...
Antonino D’Andrea   +3 more
doaj   +1 more source

Road Accident Data, 1998

open access: yes, 2000
copyright UK Data Service and data collection copyright owner.Road accident statistics are collected from information about personal injury road accidents and their consequent casualties, to a common national standard.
Department of the Environment, Transport and the Regions, Road Accidents Branch
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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