Results 71 to 80 of about 4,722,044 (303)

Dignidad, Comunidad y Poder: Make the Road New York 2010 Victories [PDF]

open access: yes, 2010
Brochure listing Make the Road New York’s victories during ...
Make the Road New York
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Operating speed as a key factor in studying the driver behaviour in a rural context

open access: yesTransport, 2016
The research aims to explore the effects of geometric road features on driver speed behaviour in order to identify unsafe road segments where high reductions in speed between successive road elements occur.
Francesca Russo   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

A functional road classification with data mining techniques

open access: yesTransport, 2014
The current international road standards, in order to give organization and safety, promote the classification of roads according to their technical and functional characteristics beyond their administrative membership, but the procedures are yet ...
Antonino D’Andrea   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Economically Optimal Road Subnetwork

open access: yesCommunications, 2014
The paper deals with the following situation: An area is served by a transportation network, usually the road one. The current quality of the network is not satisfactory for the owner (e.g.
Anna Cerna, Jan Cerny, Vladimir Pribyl
doaj   +1 more source

A Joint 3D-2D based Method for Free Space Detection on Roads

open access: yes, 2018
In this paper, we address the problem of road segmentation and free space detection in the context of autonomous driving. Traditional methods either use 3-dimensional (3D) cues such as point clouds obtained from LIDAR, RADAR or stereo cameras or 2 ...
Arora, Chetan   +4 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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