Results 41 to 50 of about 2,546 (253)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Real-Time Road Quality Assessment Using Smartphones and Cloud Lambda Architecture

open access: yesMATEC Web of Conferences, 2019
In this paper, the authors are proposing a computer system built in the cloud-computing fashion for the collection of data from smartphones to achieve a crowdsensing-based quality assessment of roads, as well as detection, identification, and assessment ...
Badurowicz Marcin, Cieplak Tomasz
doaj   +1 more source

Speed Bump and Pothole Detection Using Deep Neural Network with Images Captured through ZED Camera

open access: yesApplied Sciences, 2023
The condition of the roads where cars circulate is of the utmost importance to ensure that each autonomous or manual car can complete its journey satisfactorily.
José-Eleazar Peralta-López   +8 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Bump Modeling and Vehicle Vertical Dynamics Prediction

open access: yesAdvances in Mechanical Engineering, 2014
During a journey, motor vehicles are subjected to different types of irregularities in the pavement. Some of these irregularities are introduced for a specific purpose over a stretch of road to slow down the vehicle at certain road points.
Daniel Garcia-Pozuelo   +3 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Dynamic amplification factor for bridges with span length from 10 to 35 meters

open access: yesEngineering Structures and Technologies, 2015
Heavy traffic on the bridge cause not only static effects, but also dynamic effects. These effects can be indicated by different dynamic parameters like – natural frequency, bridge logarithmical decrement, bridge acceleration and dynamic amplification ...
Ilze Paeglite   +2 more
doaj   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung   +7 more
wiley   +1 more source

Speed bump detection on LiDAR point cloud for autonomous vehicles

open access: yesJournal of Electrical Systems and Information Technology
Speed bump detection is paramount for ensuring the safe and comfortable operation of autonomous vehicles while complying with traffic regulations. Detecting speed bumps well in advance enables timely brake application, ensuring a smooth travel experience
Bhaskar Anand, Rajalakshmi Pachamuthu
doaj   +1 more source

The Correlation between Vehicle Vertical Dynamics and Deep Learning-Based Visual Target State Estimation: A Sensitivity Study

open access: yesSensors, 2019
Automated vehicles will provide greater transport convenience and interconnectivity, increase mobility options to young and elderly people, and reduce traffic congestion and emissions.
Yannik Weber, Stratis Kanarachos
doaj   +1 more source

Home - About - Disclaimer - Privacy