Results 61 to 70 of about 51,553 (340)

The influence of the C+N+O abundances on the determination of the relative ages of Globular Clusters: the case of NGC 1851 and NGC 6121 (M4) [PDF]

open access: yes, 2009
The color magnitude diagram (CMD) of NGC 1851 presents two subgiant branches (SGB), probably due the presence of two populations differing in total CNO content. We test the idea that a difference in total CNO may simulate an age difference when comparing
A. P. Milone   +54 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Real-Time Road Quality Assessment Using Smartphones and Cloud Lambda Architecture

open access: yesMATEC Web of Conferences, 2019
In this paper, the authors are proposing a computer system built in the cloud-computing fashion for the collection of data from smartphones to achieve a crowdsensing-based quality assessment of roads, as well as detection, identification, and assessment ...
Badurowicz Marcin, Cieplak Tomasz
doaj   +1 more source

Experimental Attempt on Walking Behavior and Stress Assessment in a Completely Darkened Tunnel

open access: yesInfrastructures, 2021
In case of massive fire incidents in tunnels, ceiling lights are covered by dense smoke, and pedestrians must evacuate in the dark tunnel with almost zero visibility.
Miho Seike   +5 more
doaj   +1 more source

Near-Infrared Properties of Metal-poor Globular Clusters in the Galactic Bulge Direction [PDF]

open access: yes, 2010
Aims. J, H, and K' images obtained from the near-infrared imager CFHTIR on the Canada-France-Hawaii Telescope are used to derive the morphological parameters of the red giant branch (RGB) in the near-infrared color-magnitude diagrams for 12 metal-poor ...
Bellazzini   +63 more
core   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Bump Modeling and Vehicle Vertical Dynamics Prediction

open access: yesAdvances in Mechanical Engineering, 2014
During a journey, motor vehicles are subjected to different types of irregularities in the pavement. Some of these irregularities are introduced for a specific purpose over a stretch of road to slow down the vehicle at certain road points.
Daniel Garcia-Pozuelo   +3 more
doaj   +1 more source

The Weak Blue Bump of H2106-099 and AGN De-Reddening [PDF]

open access: yes, 1996
We present multi-frequency spectra of the Seyfert 1 galaxy H2106-099, from radio to hard X-rays, spanning over a decade of observations. The hard X-ray (2-20 keV) spectrum measured with Ginga had a Log slope of -0.80 +/- 0.02 on 1988 May 18 and -1.02 +/-
Bradt, H. V.   +5 more
core   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

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