Results 41 to 50 of about 3,613 (293)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Computer Vision-Based Detection and Classification of Road Obstacles: Systematic Literature Review
IEEE AccessRoad obstacles are a major contributor to traffic accidents, making their accurate detection and classification vital for road safety and infrastructure maintenance.
Hamza Assemlali +2 more
doaj +1 more source
Road monitoring system based on iot technology for SmartCity [PDF]
, 2020 This work is devoted to the problem of automatic road quality control, which can be used by both road repair services and common drivers. This paper provides a survey of different known techniques and algorithms of finding potholes on the road and ...
Кopiika, Anton +3 more
core +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Real-Time Road Quality Assessment Using Smartphones and Cloud Lambda Architecture
MATEC Web of Conferences, 2019 In this paper, the authors are proposing a computer system built in the cloud-computing fashion for the collection of data from smartphones to achieve a crowdsensing-based quality assessment of roads, as well as detection, identification, and assessment ...
Badurowicz Marcin, Cieplak Tomasz
doaj +1 more source
Speed Bump and Pothole Detection Using Deep Neural Network with Images Captured through ZED Camera
Applied Sciences, 2023 The condition of the roads where cars circulate is of the utmost importance to ensure that each autonomous or manual car can complete its journey satisfactorily.
José-Eleazar Peralta-López +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Bump Modeling and Vehicle Vertical Dynamics Prediction
Advances in Mechanical Engineering, 2014 During a journey, motor vehicles are subjected to different types of irregularities in the pavement. Some of these irregularities are introduced for a specific purpose over a stretch of road to slow down the vehicle at certain road points.
Daniel Garcia-Pozuelo +3 more
doaj +1 more source