Results 51 to 60 of about 51,553 (340)

SN2010jp (PTF10aaxi): A Jet-Driven Type II Supernova [PDF]

, 2011
We present photometry and spectroscopy of the peculiar TypeII supernova (SN) 2010jp, also named PTF10aaxi. The light curve exhibits a linear decline with a relatively low peak absolute magnitude of only -15.9, and a low radioactive decay luminosity at ...
Arcavi, Iair, Ben-Ami, Sagi, Bloom, Joshua S., Butler, Nat, Cenko, S. Bradley, Frail, Dale A., Gal-Yam, Avishay, Horesh, Assaf, Kasliwal, Mansi M., Kulkarni, Shrinivas R., Law, Nicholas M., Nugent, Peter E., Ofek, Eran O., Polishook, David, Poznanski, Dovi, Quimby, Robert M., Sesar, Branimir, Smith, Nathan, Sullivan, Mark, Xu, Dong, Yaron, Ofer   +20 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Performance Evaluation of You Only Look Once v4 in Road Anomaly Detection and Visual Simultaneous Localisation and Mapping for Autonomous Vehicles

World Electric Vehicle Journal, 2023
The proliferation of autonomous vehicles (AVs) emphasises the pressing need to navigate challenging road networks riddled with anomalies like unapproved speed bumps, potholes, and other hazardous conditions, particularly in low- and middle-income ...
Jibril Abdullahi Bala, Steve Adetunji Adeshina, Abiodun Musa Aibinu   +2 more
doaj   +1 more source

Why States Save: Using Evidence to Inform How Large Rainy Day Funds Should Grow [PDF]

, 2015
As revenue and spending pressures shift along with the booms and busts of the economy, states stand to benefit from the additional flexibility provided by robust rainy day funds to smooth over unexpected bumps in the road.
Akshay Iyengar, Brenna Erford, Ethan Pollack, Jonathan Moody, Kil Huh, Robert Zahradnik, Stephen Bailey   +6 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Public Perceptions of the Midwest’s Pavements - Minnesota - Phase I (focus group) [PDF]

, 2001
This research is being conducted as part of a larger study of the public’s perceptions of state-maintained rural highway pavements in Wisconsin, Minnesota, and Iowa.
University of Wisconsin - Extension, Wisconsin Survey Research Laboratory
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Computer Vision-Based Detection and Classification of Road Obstacles: Systematic Literature Review

IEEE Access
Road obstacles are a major contributor to traffic accidents, making their accurate detection and classification vital for road safety and infrastructure maintenance.
Hamza Assemlali, Soukaina Bouhsissin, Nawal Sael   +2 more
doaj   +1 more source