Results 61 to 70 of about 50,896 (304)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Bump Modeling and Vehicle Vertical Dynamics Prediction

Advances in Mechanical Engineering, 2014
During a journey, motor vehicles are subjected to different types of irregularities in the pavement. Some of these irregularities are introduced for a specific purpose over a stretch of road to slow down the vehicle at certain road points.
Daniel Garcia-Pozuelo, Antonio Gauchia, Ester Olmeda, Vicente Diaz   +3 more
doaj   +1 more source

Dynamic amplification factor for bridges with span length from 10 to 35 meters

Engineering Structures and Technologies, 2015
Heavy traffic on the bridge cause not only static effects, but also dynamic effects. These effects can be indicated by different dynamic parameters like – natural frequency, bridge logarithmical decrement, bridge acceleration and dynamic amplification ...
Ilze Paeglite, Ainars Paeglitis, Juris Smirnovs   +2 more
doaj   +1 more source

HETE Observations of the Gamma-Ray Burst GRB030329: Evidence for an Underlying Soft X-ray Component

, 2004
An exceptionally intense gamma-ray burst, GRB030329, was detected and localized by the instruments on board the High Energy Transient Explorer satellite (HETE) at 11:37:14 UT on 29 March 2003.
A. Dullighan, A. Yoshida, C. Barraud, C. Graziani, D. Q. Lamb, E. E. Fenimore, G. B. Crew, G. Pizzichini, G. Prigozhin, G. R. Ricker, J. Braga, J. G. Jernigan, J. P. Doty, J. Villasenor, J.‐F. Olive, J.‐L. Atteia, J.‐P. Dezalay, K. Hurley, K. Takagishi, K. Torii, M. Boer, M. Galassi, M. Matsuoka, M. Suzuki, N. Butler, N. Kawai, R. Manchanda, R. Vanderspek, S. E. Woosley, Shirasaki Y., T. Q. Donaghy, T. Sakamoto, T. Tamagawa, Y. Shirasaki   +33 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Speed bump detection on LiDAR point cloud for autonomous vehicles

Journal of Electrical Systems and Information Technology
Speed bump detection is paramount for ensuring the safe and comfortable operation of autonomous vehicles while complying with traffic regulations. Detecting speed bumps well in advance enables timely brake application, ensuring a smooth travel experience
Bhaskar Anand, Rajalakshmi Pachamuthu
doaj   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

The Correlation between Vehicle Vertical Dynamics and Deep Learning-Based Visual Target State Estimation: A Sensitivity Study

Sensors, 2019
Automated vehicles will provide greater transport convenience and interconnectivity, increase mobility options to young and elderly people, and reduce traffic congestion and emissions.
Yannik Weber, Stratis Kanarachos
doaj   +1 more source

Impact of vertical traffic calming devices on environmental noise

Građevinar, 2021
Increasing numbers of people living in urban areas are being exposed to harmful action of environmental noise, which severely affects their health and quality of life.
Tamara Džambas, Vesna Dragčević, Josip Lakušić   +2 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source