Results 51 to 60 of about 43,137 (302)
JAMA, 2003 Carly Simon is singing from my car radio, reifying her old grief: Suffering was the only thing made me feel I was alive. Thought that’s just how much it cost to survive in this world. And, knowing how sorrow loves to inhabit the body, how it runs like liquid to the void, I’m nodding in agreement when three young boys swagger across the road, daring me ...
openaire +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The road user behaviour of school students in Belgium [PDF]
, 2012 The present study aimed to investigate both the on road behaviour of Belgian school students and the validity of the Adolescent Road User Behaviour Questionnaire (ARBQ) in a sample of students attending school in Belgium.
Stephens, Amanda N. +2 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Bridge roughness index as an indicator of bridge dynamic amplification
, 2006 The concept of a road roughness index for bridge dynamics is developed. The International Roughness Index (IRI) is shown to be very poorly correlated with bridge dynamic amplification as it takes no account of the location of individual road surface ...
O'Brien, Eugene J. +2 more
core +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
JGEET: Journal of Geoscience, Engineering, Environment and Technology, 2023 Pipelines are the main choice for transport oil and gas due to its resilience, reliability, safety, and lower cost. Most road crossing pipelines are located underground where protections from the loads can be used such as additional pavement. Underground
Taqiya Tsamara, IGN Wiratmaja Puja
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source