Results 31 to 40 of about 140,504 (263)
Sensors, 2021 European road safety has improved greatly in recent decades. However, the current numbers are still far away to reach the European Commission’s road safety targets.
Olatz Iparraguirre +3 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Advances in Civil Engineering, 2023 Regular maintenance keeps roads in a good working condition for users. Road maintenance can be conducted using labor and machine based methods. In this study, applicability and costs of labor-based, namely employment intensive (EI), labor intensive (LI),
Berhane Grum +8 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Cogent Engineering, 2022 The construction industry is the most important for the social, economic, and political development of countries. The road construction sector is the largest in the construction industry.
Girmay Getawa Ayalew +2 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
New Taipei City Smart Pavement Management Center and Road Maintenance Analysis
Applied SciencesThe integration of the Smart Pavement Management Center aims to improve the efficiency and quality of road maintenance in New Taipei City. This paper explores the application of the I-ROAD Reporting System and analyzes its effectiveness in providing real-
Pin-You Song +3 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Enhancing the Assessment of Winter Road Maintenance Levels with Respect to Road Safety in Lithuania
Future TransportationWinter road maintenance levels are currently determined based on criteria with weights that have not yet been scientifically validated in Lithuania. This study aims to address this gap by analyzing global practices related to winter road maintenance ...
Gytis Juchnevičius, Vytautas Grigonis
doaj +1 more source