Results 41 to 50 of about 140,504 (263)

RCM and AHP Hybrid Model for Road Network Maintenance Prioritization

The Baltic Journal of Road and Bridge Engineering, 2015
Category1 defects such as potholes significantly accelerate structural deterioration and pose imminent hazards on trunk road networks. Frequent occurrences of category1 defects have increased service disruptions on trunk road networks.
Ena E. Orugbo, Babakalli M. Alkali, Anjali DeSilva, David K. Harrison   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

State Road Pavement Maintenance

Engineering Proceedings
This paper focuses on a section of the state road D28, Bjelovar northern bypass, Republic of Croatia, which was opened to traffic in 2002. Following the expiration of the 20-year design service life, it was determined that the section required ...
Karolina Vukelić, Sanja Dimter
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

The evaluation of road maintenance programs, case study: the national road maintenance programs in West Sumatra

MATEC Web of Conferences, 2018
Currently, due to the limitation of funding, the national road maintenance programs in West Sumatra which were based on the output from IIRMS (Indonesian Integrated Road Management System) cannot be fully implemented. In order the road maintenance can be
Yuniar Haptiwi Tri, Adji Bayu Martanto, Hidayat Benny   +2 more
doaj   +1 more source

Evaluation of Attempts for Efficient Road Maintenance – Knowledge Compilation

The Baltic Journal of Road and Bridge Engineering, 2010
The objective of this study was to compile experiences regarding efforts by road authorities to satisfy the needs for efficient maintenance and the results of such efforts.
Hawzheen Karim
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stakeholder Expectation and Satisfaction in Road Maintenance

Procedia - Social and Behavioral Sciences, 2012
AbstractUnderstanding the process of stakeholder satisfaction is a prerequisite for successful stakeholder management. The expectancy disconfirmation model describes the process of stakeholder satisfaction by relating customers’ satisfaction with a product or service to discrepancy between the perceived performance of and the prior expectations about ...
Hietbrink, M., Hartmann, A., Dewulf, G.P.M.   +2 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source