Results 51 to 60 of about 140,504 (263)
EdusaintekRoads infrastructure has a very important role in supporting economic, social and cultural activities of a region. Road maintenance is an activity related to road maintenance and repairs that are necessary and planned to maintain road conditions so it ...
Tiny Mananoma +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
RECENT DEVELOPMENT IN ROAD-TRAFFIC, ROAD-CONSTRUCTION AND MAINTENANCE. [PDF]
Minutes of the Proceedings of the Institution of Civil Engineers, 1911 n ...
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Experimental investigation on fatigue and fracture behaviour of cold recycling materials
Transportation EngineeringCold Recycled Material (CRM) has emerged as a highly innovative road construction material, offering numerous advantages over conventional Hot Mix Asphalt (HMA), such as reduced construction costs, decreased energy consumption, and enhanced resistance to
Ahmed Al-Mohammedawi, Konrad Mollenhauer
doaj +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Innovative Road Maintenance: Leveraging Smart Technologies for Local Infrastructure
DesignsRoads are essential for economic development, facilitating the circulation of services and resources. This research seeks to provide local governments with a comprehensive framework to enhance road maintenance, focusing on the surface and functional ...
Laura Fabiana Jáuregui Gallegos +2 more
doaj +1 more source
The impact of drainage towards roads in maintenance cost
MATEC Web of Conferences, 2018 An ideal road infrastructure has a low cost for maintenance and better performance of the roads and drainage systems. The disintegrated maintenance system between the roads and drainage is the major cause of an increasing road maintenance cost. Therefore,
Ismiyani Erna +2 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source