Results 61 to 70 of about 140,504 (263)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Assessment of Intelligent Unmanned Maintenance Construction for Asphalt Pavement Based on Fuzzy Comprehensive Evaluation and Analytical Hierarchy Process

Buildings
Conventional human-involved maintenance methods for asphalt pavement pose significant challenges when applied to high-traffic road sections, often leading to congestion and safety risks, as well as reduced maintenance efficiency.
Gensheng Hu, Gongzuo Shi, Runhua Zhang, Jianfeng Chen, Haichang Wang, Junzhe Wang   +5 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Contracting for Road Maintenance in the Netherlands—The Downside of Performance-Based Contracting

Infrastructures, 2019
A trend towards performance-based contracting (PBC) can be observed in public infrastructure maintenance. PBC is an approach of tying the contractor’s payment to specified performance. We investigated PBC for the maintenance of highways and roads in the Netherlands, identifying issues ultimately resulting in poor contractor performance. The PBC-induced
Gelderman, Cees J., Semeijn, Janjaap, de Vries, Sjerp   +2 more
openaire   +4 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Quantification and Valuation of Travel Time Costs Due to Road Works in the Integrated System of Road Economic Evaluation

Civil and Environmental Engineering, 2019
Software ISEH (Integrated system of road projects economic evaluation) evaluates variants of road repair and maintenance technologies. The economic assessment is based on Cost Benefit Analysis indicators (net present value, internal rate of return, pay ...
Trojanová M., Margorínová M., Kowalska-Koczwara A.   +2 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Advancing road maintenance with EfficientDet-based pothole monitoring [PDF]

Serbian Journal of Electrical Engineering
Effective road maintenance is crucial for ensuring safe and efficient transportation but is often compromised by the widespread occurrence of potholes.
Jenefa Archpaul, Taurshia Antony, Kuriakose Bessy Mani, Kumar Edward Naveen Vijaya, Lincy Archpaul   +4 more
doaj   +1 more source

Model of Investment in Road Maintenance as Preservation of Road Infrastructure Value

Promet - Traffic&Transportation, 1970
The aim of research is to indicate the failure to use information on road depreciation in the process of making decisions about investment into road maintenance. Depreciation as accountancy category has not been sufficiently used as managerial information and its status has been marginalised.
Grgo Luburić, Gordana Miljković, Krešimir Buntak   +2 more
openaire   +4 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source