Results 51 to 60 of about 1,390,290 (339)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Road Topology Refinement via a Multi-Conditional Generative Adversarial Network

Sensors, 2019
With the rapid development of intelligent transportation, there comes huge demands for high-precision road network maps. However, due to the complex road spectral performance, it is very challenging to extract road networks with complete topologies ...
Yang Zhang, Xiang Li, Qianyu Zhang
doaj   +1 more source

Fast simulation for Road Traffic Network [PDF]

RAIRO - Operations Research, 2001
Summary: In this paper we present a method to perform fast simulation of large Markovian systems. This method is based on the use of three concepts: Markov chain uniformization, event-driven dynamics, and modularity. An application of urban traffic simulation is presented to illustrate the performance of our approach.
Ycart, Bernard, Jungblut, R., Plateau, B., Stiwart, W.   +3 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Change Detection and Incremental Updates for Multi-Source Road Networks Considering Topological Consistency

ISPRS International Journal of Geo-Information
Vector road networks are vital components of intelligent transportation systems and electronic navigation maps. There is a pressing need for efficient and rapid dynamic updates for road network data. In this paper, we propose a series of methods designed
Xiaodong Wang, Dongbao Zhao, Xingze Li, Nan Jia, Li Guo   +4 more
doaj   +1 more source

Synthetic European road freight transport flow data

Data in Brief, 2022
This data article describes a dataset on European road freight traffic. The dataset includes truck traffic flows between 1675 regions all over Europe. In addition to the road freight flows in tons as well as number of vehicles, the dataset also contains ...
Daniel Speth, Verena Sauter, Patrick Plötz, Tim Signer   +3 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Method for quickly building road network model of open-pit mine based on grid refinement

Meitan xuebao
Constructing the road network in open-pit mining areas is a crucial step for intelligent scheduling and autonomous driving of trucks in these regions. However, given the intricate road conditions, extensive GPS trajectory data from mining vehicles, and ...
Qinghua GU, Fengyuan HU, Qian WANG, Xiaobo CHAI, Dan WANG, Xinxin JING   +5 more
doaj   +1 more source

The backbone of urban street networks: Degree distribution and connectivity characteristics

Advances in Mechanical Engineering, 2017
This article explores the backbone of urban street networks to reflect the characteristics of the overall network. The model representing the connection of urban road elements based on traffic properties is constructed and then applied to the traffic ...
Wei Zhang, Shiguang Wang, Xiujuan Tian, Dexin Yu, Zhaosheng Yang   +4 more
doaj   +1 more source