Results 71 to 80 of about 223,497 (264)

Toll caps in privatized road networks [PDF]

European Journal of Operational Research, 2019
25 pages, 8 ...
Tobias Harks, Marc Schröder 0002, Dries Vermeulen   +2 more
openaire   +4 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Discrimination and Prediction of Traffic Congestion States of Urban Road Network Based on Spatio-Temporal Correlation

IEEE Access, 2020
By analyzing and predicting the traffic states of urban road network, the formation of traffic congestion can be effectively alleviated, so as to improve the traffic capacity of urban road network.
Zhi Chen, Yuan Jiang, Dehui Sun
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The searchlight problem for road networks

Theoretical Computer Science, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Dariusz Dereniowski, Hirotaka Ono 0001, Ichiro Suzuki, Lukasz Wrona, Masafumi Yamashita, Pawel Zylinski   +5 more
openaire   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

SP-GEM: Spatial Pattern-Aware Graph Embedding for Matching Multisource Road Networks

ISPRS International Journal of Geo-Information
Identifying correspondences of road segments in different road networks, namely road-network matching, is an essential task for road network-centric data processing such as data integration of road networks and data quality assessment of crowd-sourced ...
Chenghao Zheng, Yunfei Qiu, Jian Yang, Bianying Zhang, Zeyuan Li, Zhangxiang Lin, Xianglin Zhang, Yang Hou, Li Fang   +8 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Bounded Asymmetry in Road Networks

Scientific Reports, 2019
AbstractRoad networks are a classical stage for applications in network science and graph theory. Meanwhile, many combinatorial problems that arise in road networks are computationally intractable. Thus, an attractive way of tackling them is through efficient heuristics with provable performance guarantees, better known as approximation algorithms ...
Martínez Mori, Juan C., Samaranayake, Samitha   +1 more
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source