Results 41 to 50 of about 119,099 (264)
A link model approach to identify congestion hotspots
Royal Society Open Science, 2022 Congestion emerges when high demand peaks put transportation systems under stress. Understanding the interplay between the spatial organization of demand, the route choices of citizens and the underlying infrastructures is thus crucial to locate ...
Aleix Bassolas +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The traffic phases of road networks [PDF]
Transportation Research Part C: Emerging Technologies, 2011 We study the relation between the average traffic flow and the vehicle density on road networks that we call 2D-traffic fundamental diagram. We show that this diagram presents mainly four phases. We analyze different cases. First, the case of a junction managed with a priority rule is presented, four traffic phases are identified and described, and a ...
Farhi, Nadir +2 more
openaire +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The SSP-Tree: A Method for Distributed Processing of Range Monitoring Queries in Road Networks
ISPRS International Journal of Geo-Information, 2017 This paper addresses the problem of processing range monitoring queries, each of which continuously retrieves moving objects that are currently located within a given query range.
HaRim Jung, Ung-Mo Kim
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Acta Polytechnica CTU Proceedings, 2022 Assessing flood risks on road infrastructures is critical for the definition of mitigation strategies and adaptation processes. Some efforts have been made to conduct a regional flood risk assessment to support the decision-making process of exposed ...
Erica Arango +4 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Jurnal Ilmiah SINERGINatural disasters in the form of floods and erosion in remote area road networks pose challenges for the government. The involvement of community-based disaster management can make it easier for stakeholders to carry out disaster mitigation intelligently.
Andri Irfan Rifai +4 more
doaj +1 more source