Results 61 to 70 of about 119,099 (264)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Active travel modelling: a methodological approach to networks for walking and cycling commuting analysis

Journal of Physics: Complexity
Walking and cycling, commonly referred to as active travel, have become integral components of modern transport planning. Recently, there has been growing recognition of the substantial role that active travel can play in making cities more liveable ...
Ivann Schlosser, Valentina Marin, Richard Milton, Elsa Arcaute, Michael Batty   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Method for the Identification and Classification of Zones with Vehicular Congestion

ISPRS International Journal of Geo-Information
Persistently, urban regions grapple with the ongoing challenge of vehicular traffic, a predicament fueled by the incessant expansion of the population and the rise in the number of vehicles on the roads.
Gary Reyes, Roberto Tolozano-Benites, Laura Lanzarini, César Estrebou, Aurelio F. Bariviera, Julio Barzola-Monteses   +5 more
doaj   +1 more source

An evaluation of different provision strategies for scaled-up container-based sanitation

H2Open Journal, 2021
Container-based sanitation (CBS) is increasingly used to provide safely managed sanitation in low-income urban settlements. However, questions remain around the viability of scaling up the technology, partly because it relies on regular emptying and ...
Charlie Ferguson, Adrian Mallory, Paul Hutchings, Claire Remington, Erica Lloyd, Domenic Kiogora, Fiona Anciano, Alison Parker   +7 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A Fiber Optic PD Sensor Using a Balanced Sagnac Interferometer and an EDFA-Based DOP Tunable Fiber Ring Laser

Sensors, 2014
A novel fiber-optic acoustic sensor using an erbium-doped fiber amplifier (EDFA)-based fiber ring laser and a balanced Sagnac interferometer for acoustic sensing of the partial discharge (PD) in power transformers is proposed and demonstrated.
Lutang Wang, Nian Fang, Chunxu Wu, Haijuan Qin, Zhaoming Huang   +4 more
doaj   +1 more source