Results 81 to 90 of about 148,828 (311)
Test Networks from "Measuring the Structure of Road Networks"
, 2007 The networks used in Figure 5 (Xie and Levinson (2007) Measuring the Structure of Road Networks) are in 16 simple ASCII node and link tables. The 12 derived network structures are obtained by using a simulation model called the degeneration model (Xie ...
Levinson, David M, Xie, Feng
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Diversified Routing Queries in Dynamic Road Networks
IEEE Access, 2019 Route planning and recommendation are increasingly important in the recent two decades. In this light, we propose and study novel diversified routing (DR) queries that discover the most convenient routes in dynamic road networks, where travel time ...
Jianmin Li, Ying Zhong, Shunzhi Zhu
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Toll caps in privatized road networks [PDF]
European Journal of Operational Research, 2019 25 pages, 8 ...
Tobias Harks +2 more
openaire +3 more sources
, 2020 Road markings constitute one of the most important elements of the road. Moreover, they are managed according to specific standards, including a criterion for a luminous contrast, which can be referred to as retroreflection.
Taehee Lee +3 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Journal of Physics: ComplexityWalking and cycling, commonly referred to as active travel, have become integral components of modern transport planning. Recently, there has been growing recognition of the substantial role that active travel can play in making cities more liveable ...
Ivann Schlosser +4 more
doaj +1 more source
Fast simulation for Road Traffic Network [PDF]
RAIRO - Operations Research, 2001 Summary: In this paper we present a method to perform fast simulation of large Markovian systems. This method is based on the use of three concepts: Markov chain uniformization, event-driven dynamics, and modularity. An application of urban traffic simulation is presented to illustrate the performance of our approach.
Ycart, Bernard +3 more
openaire +2 more sources