Results 111 to 120 of about 919,114 (299)

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

open access: yesAdvanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu   +20 more
wiley   +1 more source

Unified approach for detecting traffic signs and potholes on Indian roads

open access: hybrid, 2021
Satish Kumar Satti   +3 more
openalex   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

open access: yesAdvanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon   +8 more
wiley   +1 more source

Identification of TPRA1 as a Novel Receptor and Predictive Biomarker for Oncolytic Virus M1

open access: yesAdvanced Science, EarlyView.
This study identifies transmembrane protein adipocyte‐associated 1 (TPRA1) as a novel receptor for oncolytic virus M1 (OVM). TPRA1's ectodomain binds OVM particles, while its intracellular domain facilitates virus internalization, promoting efficient viral entry.
Linyi Hu   +20 more
wiley   +1 more source

Methodological Traffic Load Survey of the Road Sv. Leopolda Bogdana Mandica with a Queuing Model [PDF]

open access: yes
The traffic in Osjecko–Baranjska County is strongly marked by the regional road named Sv. Leopolda Bogdana Mandica (so-called “Cepinska cesta”). With its high traffic density and specific significance, this road is negatively characterized by traffic ...
Marija Hornis, Martina Bris
core  

The impacts for stone curlews of increased traffic on the A11. Model and predictions [PDF]

open access: yes, 2009
Stone curlew nest density in the Breckland region of Eastern England was shown to be negatively related to ‘nearby’ housing density and ‘nearby’ trunk road traffic (based on new traffic data for the period 1988-2006).
Clarke, Ralph T., Liley, D., Sharp, J.
core  

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

open access: yesAdvanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu   +11 more
wiley   +1 more source

Research progress on the current status and influencing factors of road traffic injuries among online delivery drivers

open access: yesZhongguo gonggong weisheng
In recent years, with the continuous development of the take-out industry, the traffic accidents involving online delivery drivers have been frequent, posing a major threat to road traffic safety.
Rusi YANG, Juan SONG, Ming HU
doaj   +1 more source

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