Results 41 to 50 of about 9,204 (216)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Test diagnostics of engine systems in passenger cars [PDF]
FME Transactions, 2020 One of the priority directions in the development of instrument diagnostics of car engines is test diagnostics. The main advantages of such testing are: significant coverage of the diagnosed engine systems; high informativeness and reliability of the ...
Gritsenko A. +3 more
doaj
Change management in road transport companies by the models of strategic management [PDF]
Tehnika, 2017 Change management in the road transport companies in modern conditions requires from the management of those companies to permanently and quickly respond to changes, adapt to changes and, if necessary, implement the necessary changes.
Salamadija Veselin M. +1 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Sustainable Transport of Goods Using Combined Transport Solutions: The Case of EU
Naše Gospodarstvo, 2021 This paper analyzes the importance of bimodal solutions in the rail-road transport of goods with an emphasis on the aspect of ecology within the geographical region of EU-28.
Minárik Marek
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Study on the Evaluation Index of Logistics Safety of Hazardous Chemicals
Chemical Engineering Transactions, 2016 In recent years, with the rapid development of road transport, the leakage accidents of hazardous chemicals caused by road transport are also increasing, which seriously threaten people's lives and property safety.
Y.Q. Lian
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
MOBILE SOLUTIONS IN ROAD TRANSPORT
TRANSPORT, 2007 The article dwells on the aspects of mobile solutions of public information and transport. The work presents major decision making principles based on object positioning and a system of positioning‐based GSM solutions. The newly developed remote identification systems for transport facilities and goods and passenger transport and their schematic view ...
Batarlienė, Nijolė, Baublys, Adolfas
openaire +4 more sources