Results 61 to 70 of about 1,053,772 (311)

Urban Air Mobility: Viability of Hub-Door and Door-Door Movement by Air [PDF]

, 2020
Owing to a century of innovation in connected and automated aircraft design, for the rst time in history, air transport presents a potential competitive alternative to road, for hub-to-door and door-to-door urban services.
Bulusu, Vishwanath, Sengupta, Raja
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Bicycling tasks relation to stability measures during alcohol intoxication

Traffic Safety Research
Bicycling accidents are a major traffic safety problem and are deemed ‘an unacceptable human and social price for EU citizens’. One of the major causes for bicycling accidents is loss of balance. A related influencing factor is alcohol intoxication.
Jan Andersson, Henriette Wallén Warner, Peter Andrén   +2 more
doaj   +1 more source

Road Expansion and Urban Highways: Consequences Outweigh Benefits in Kathmandu [PDF]

, 2017
Rapid urbanization has transformed Kathmandu Valley, Nepal, one of the fastest growing metropolitan regions in South Asia. This urbanization, in turn, is leading to considerable social, economic, and environmental stress.
Chand, Priyankar Bahadur, Gurung, Anobha, Khanal, Prashanta   +2 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Improvement in strength calculation for pavement structure of rail station areas

MATEC Web of Conferences, 2017
The paper discusses the issue of how to increase the durability of road pavements at stations. At the same time, the behavior of asphalt-concrete layers is considered taking into account thermoreological properties and their materials.
Mozgovyi Vladimir, Baran Sergei, Kutsman Alexander   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Smart Transport in road transport infrastructure

IOP Conference Series: Materials Science and Engineering, 2020
Abstract Introduction of new technologies in cities through effective interaction between people and modern IT management tools has introduced the concept of «smart city» able to independently manage its own resources, energy, space and information to improve life quality. One of the main components of a «smart city» is «smart transport»
S A Evtiukov, E V Kurakina, S S Evtiukov
openaire   +1 more source

In-depth research into rural road crashes [PDF]

, 2008
This report was produced under an agreement between Transport SA and the Road Accident Research Unit formed in the late 1990s. Due to various delays in the publication of this report, Transport SA has since become the Department for Transport, Energy and
Baldock, M., Kloeden, C., McLean, J.
core