Results 71 to 80 of about 1,053,772 (311)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Appraisal of Road Transport Policy Reform in Nigeria: A Case of Infrastructural Deficit

open access: yesJournal of Governance and Public Policy, 2019
The study examined the road transport system reform in Nigeria. This was intending to assess the adequacy of road transport reform in Nigeria. The study employed both primary and secondary data. This study employed a stratified sampling technique for the
Anthony Kayode Oroleye
doaj   +1 more source

Road Pricing and Older People: Identifying Age-Specific Differences Between Older and Younger People's Attitudes, Social Norms and Pro-Social Value Orientations to Road Pricing. [PDF]

open access: yes, 2009
The implementation of road pricing schemes is likely to be an inescapable measure in the future of managing road transport demand in highly congested environments.
Nikitas, Alexandros
core  

Modelling Planner-Carrier Interactions in Road Freight Transport: Optimization of Road Maintenance Costs Via Overloading Control

open access: yes, 2013
A bi-level modelling approach is proposed to represent the interaction between the vehicle loading practices of road freight transport carriers, and the decisions of a road planning authority responsible both for road maintenance and for the enforcement ...
Fowkes, AS, Moreno, E, Watling, DP
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

European perspectives on a new fiscal framework for transport [PDF]

open access: yes, 2004
This chapter presents an overview of changes in transport taxation in European countries to promote more sustainable transport. A number of changes in the framework of car taxation have resulted in some useful environmental gains.
Lane, Ben   +2 more
core   +1 more source

Racjonalność gospodarowania energią w sektorze transportu w UE [PDF]

open access: yes, 2014
The main objective of this article was to make a quantitative and qualitative attempt to examine the relationship and the correlations between the development of transport and fuel efficiency of resource use. The analysis has shown that road transport
Motowidlak, Urszula
core   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Evaluation of intelligent transport systems impact on school transport safety

open access: yesMATEC Web of Conferences, 2017
The integrated system of safe transport of children to school using Intelligent Transport Systems was developed and implemented in four locations across Europe under the Safeway2School (SW2S) project, funded by the EU. The SW2S system evaluation included
Jankowska-Karpa Dagmara   +1 more
doaj   +1 more source

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