Results 51 to 60 of about 9,204 (216)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Research of multimodal transport potential of major cities in China based on the satellite remote sensing [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
By two or more modes of transportation to connect with each other and complete the transport process, multimodal transport could significantly improve transport efficiency, reduce costs, while promote energy conservation and emission reduction, compared ...
H. Dai, H. Dai, Z. Fu, T. Zhang, G. Wang, L. Miao, T. Liu, Y. Zou   +7 more
doaj   +1 more source

Transporting down the road to dehydration [PDF]

Blood, 2015
In this issue of Blood, Brown and colleagues provide strong evidence that erythrocyte hydration is an important modifier of disease severity in sickle cell disease (SCD ...
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Bicycling tasks relation to stability measures during alcohol intoxication

Traffic Safety Research
Bicycling accidents are a major traffic safety problem and are deemed ‘an unacceptable human and social price for EU citizens’. One of the major causes for bicycling accidents is loss of balance. A related influencing factor is alcohol intoxication.
Jan Andersson, Henriette Wallén Warner, Peter Andrén   +2 more
doaj   +1 more source

Improvement in strength calculation for pavement structure of rail station areas

MATEC Web of Conferences, 2017
The paper discusses the issue of how to increase the durability of road pavements at stations. At the same time, the behavior of asphalt-concrete layers is considered taking into account thermoreological properties and their materials.
Mozgovyi Vladimir, Baran Sergei, Kutsman Alexander   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Roads toward environmentally sustainable transport [PDF]

Transportation Research Part A: Policy and Practice, 1994
This paper explores roads toward environmentally sustainable transport, with particular emphasis on the bottlenecks preventing the achievement of policy objectives of reconciling the economic interests of the transport sector with environmental constraints.
openaire   +5 more sources