Results 81 to 90 of about 1,034,355 (367)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

The severity of driver fatigue in terms of line crossing: a pilot study comparing day- and night time driving in simulator

European Transport Research Review, 2017
Introduction The overall aim of this study is to compare day-time driving with night-time driving looking at line crossings during self-reported sleepiness and long blinks.
Anna Anund, Carina Fors, Christer Ahlstrom   +2 more
doaj   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

FEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

Reducing Carbon emissions through transport taxation, GFC Briefing Paper 6 [PDF]

, 2010
Road transport and aviation are, or are becoming, major sources of carbon emissions which will need to be reduced if the UK’s carbon dioxide (CO2) reduction targets are to be met.
Ekins, Paul, Potter, Stephen
core  

Forecasting environmental equity: Air quality responses to road user charging in Leeds, UK [PDF]

, 2005
Sustainable development requires that the goals of economic development, environmental protection and social justice are considered collectively when formulating development strategies. In the context of planning sustainable transport systems, trade-offs
Adebowale, Agyeman, Agyeman, Bae, Bhaskar, Boardman, Bowen, Bracken, Brainard, Bullard, Capek, Carslaw, Cook, Cutter, Dobson, Dolk, Dunion, Eggleston, Elliott, European Commission, Feitelson, Forkenbrock, Freeman, Goodchild, Gordon Mitchell, Jerrett, Liu, Lucas, Lyons, McLeod, Mitchell, Mitchell, Mitchell, Mitchell, Namdeo, Pennycook, Stevenson, Taylor, Townsend, UN ECE, UN ECE, Van Vliet, Walker, Warner, WCED, Wilkinson   +45 more
core   +1 more source

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

Setting the market free: deregulation of the bus industry. 4th Smeed Memorial Lecture, 29th October 1987. [PDF]

, 1987
[FIRST PARAGRAPH]Though he was not himself an economist, Reuben Smeed is well known to transport economists as the chairman of a committee which, in the early sixties, examined the use of congestion charges to obtain a rational use of scarce urban road ...
Gwilliam, K.M.
core  

Roads toward environmentally sustainable transport [PDF]

Transportation Research Part A: Policy and Practice, 1994
This paper explores roads toward environmentally sustainable transport, with particular emphasis on the bottlenecks preventing the achievement of policy objectives of reconciling the economic interests of the transport sector with environmental constraints.
openaire   +6 more sources

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source