Results 11 to 20 of about 1,200,904 (255)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim +8 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley +1 more source
Effects of Roads on Black Bear Distribution in Southern Vermont [PDF]
, 2017 The American black bear (Ursus americanus) is a wide-ranging, large carnivore species that makes use of multiple habitat types throughout the year.
Drasher, Caitlin E.
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Bumpy Roads Ahead: America's Roughest Rides and Strategies to Make our Roads Smoother [PDF]
, 2013 These days, potholes and pavement deterioration make it a challenge to keep the wheel steady on America's roads and highways. More than a quarter of the nation's major urban roadways -- highways and major streets that are the main routes for commuters ...
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Toll roads: a thin end of the wedge? – if only they were [PDF]
, 2012 Nigel Keohane argues that privatising roads could lead to new road construction that would create jobs and bring substantial economic gains from reduced congestion. A politically feasible scheme could also include shared ownership for road users through ‘
Keohane, Nigel
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Ripples and Grains Segregation on Unpaved Road
, 2019 Ripples or corrugations are common phenomena observed in unpaved roads in less developed countries or regions. They cause several damages in vehicles leading to increased maintenance and product costs.
Bernardes, Americo T. +1 more
core +1 more source