Results 31 to 40 of about 284,942 (261)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Gastroenterology, 1999 Medical diagnosis generally requires observed anatomical or physiological abnormalities. Description of the illness and criteria for its diagnosis follow naturally. Recognized symptoms can then be attributed to the observation, and a diagnosis predictably follows. In the case of the functional disorders, such a process is impossible.
openaire +4 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Transport, 2018 The formulation of scenarios for developing the urban transport infrastructure requires decisions mainly based on the intuition of experts in transport and highly influenced by public interest groups, business entities and political opinions.
Vytautas Dumbliauskas +2 more
doaj +1 more source
Student experiences of Open Educational Practices: a systematic literature review
Je-LKS: Journal of E-Learning and Knowledge Society, 2020 The purpose of this literature review was to gain a deeper understanding of student experiences of open educational practices (OEP). The research was conducted against the backdrop of a small, publicly funded university in Canada that offers a masters ...
Jo Axe +3 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Roads policing: Current context and imminent dangers [PDF]
, 2008 © The Authors 2008. Published by Oxford University Press on behalf of CSF Associates: Publius, Inc. All rights reserved. For permissions please e-mail: journals.permissions@oxfordjournals.org. The final version of this paper can be accessed at the link
Corbett, C
core +1 more source
Techno-surveillance of the roads: High impact and low interest [PDF]
, 2008 Copyright © 2010 Palgrave Macmillan. This is a post-peer-review, pre-copyedit version of an article published in Crime Prevention and Community Safety.
Corbett, C
core +5 more sources
The role of boundary and initial conditions for dynamical seasonal predictability [PDF]
Nonlinear Processes in Geophysics, 2003 The importance of initial state and boundary forcing for atmospheric predictability is explored on global to regional spatial scales and on daily to seasonal time scales.
T. J. Reichler, J. O. Roads
doaj
Evaluation of frost blanket layer strength using different devices
Građevinar, 2019 The relationship between the static and dynamic deflection modulus is presented in the paper, and a correlation between the FBL physical and strength indicators is determined. The correction coefficients of dynamic measurements, as related to static beam
Lina Bertulienė +3 more
doaj +1 more source