Results 31 to 40 of about 1,200,904 (255)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Effects of Roads and Traffic on Wildlife Populations and Landscape Function Road Ecology is Moving toward Larger Scales [PDF]
, 2011 Road ecology has developed into a significant branch of ecology with steady growth in the number of refereed journal articles, books, conferences, symposia, and “best practice” guidelines being produced each year. The main objective of this special issue
Clevenger, A.P. +3 more
core +4 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Scale Invariance in Road Networks [PDF]
, 2006 We study the topological and geographic structure of the national road networks of the United States, England and Denmark. By transforming these networks into their dual representation, where roads are vertices and an edge connects two vertices if the ...
A. Fabrikant +9 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The Grading of Earth Roads [PDF]
, 1924 Exact date of bulletin unknown.PDF pages ...
Hooley, Clyde H., Overholt, Virgil
core
Integrating spatial and temporal approaches for explaining bicycle crashes in high-risk areas in Antwerp (Belgium) [PDF]
, 2019 The majority of bicycle crash studies aim at determining risk factors and estimating crash risks by employing statistics. Accordingly, the goal of this paper is to evaluate bicycle-motor vehicle crashes by using spatial and temporal approaches to ...
Chang, SK Jason +4 more
core +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
En route to safer roads: How road structure and road classification can affect road safety
, 2023 Atze Dijkstra investigated whether road safety can be improved by making changes in road structure and road categorization according to the functional requirements of Sustainable Safety. One of these demands is that the fastest route is also the safest route. This is often not the case in practice.
openaire +2 more sources
Roadless space and logging in intact forest landscapes of the Congo Basin [PDF]
, 2016 Background: Forest degradation in tropical regions is often associated with roads built for selective logging. Forest areas that are not accessible by roads are considered valuable because they provide habitat that is not immediately impacted by major ...
Gourlet-Fleury, Sylvie +5 more
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