Results 51 to 60 of about 96,564 (268)
Seeds of Self-Determination: How Snuneymuxw Built Economic Power
Journal of Aboriginal Economic DevelopmentThis case study examines the development of the Petroglyph Development Group (PDG), the economic organization of the Snuneymuxw First Nation (SFN), tracing its growth from initial community-based ventures to larger undertakings such as the co-management
Greg Moynan, Tasha Brooks
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
A Monitoring System for Sustainable Urban Mobility Plans
The Baltic Journal of Road and Bridge Engineering, 2019 Sustainable Urban Mobility Plans are developed in Europe rapidly. The future initiative is expected will change the image of European cities and will make transport systems efficacious, thus reducing congestion, decreasing air pollution, and offering ...
Jonas Damidavičius +2 more
doaj +1 more source
Manuscrito, 2020 Abstract Roads to Reference offers a highly valuable contribution to the theory of reference. The arguments in this book are quite convincing and the overall picture presented in it is quite attractive. In what follows I would like to present some critical comments regarding the first chapter of the book, Demonstratives and Conflicting Intentions.
openaire +4 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Approach to rational calculation of superelevation in dual gauge track
Transport, 2018 One of the technical possibilities to solve a gauge crossing is to install a dual gauge. This solution has several advantages and disadvantages discussed in this paper.
Inesa Gailienė +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
IGIP and the of engineering education in Russia and in the world
Высшее образование в России, 2022 The paper presents the basic directions of modernization IGIP curriculum for training and professional development of teachers of engineering universities, which were approved at a meeting of the Executive Committee of the International Society for ...
Vjacheslav M. Prikhodko, A. N. Solovyev
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source