Results 61 to 70 of about 638,870 (367)
Approach to rational calculation of superelevation in dual gauge track
Transport, 2018 One of the technical possibilities to solve a gauge crossing is to install a dual gauge. This solution has several advantages and disadvantages discussed in this paper.
Inesa Gailienė +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Vision Hampton Roads : economic performance measures, 2010 DASHBOARD. [PDF]
Mission: Provide leadership to focus on the strategic issues that will improve Hampton Roads' competitive position in the global economy.Goal: With proper foresight, continuous planning and dynamic economic development, Hampton Roads will be recognized ...
Hampton Roads Partnership
core
IGIP and the of engineering education in Russia and in the world
Высшее образование в России, 2022 The paper presents the basic directions of modernization IGIP curriculum for training and professional development of teachers of engineering universities, which were approved at a meeting of the Executive Committee of the International Society for ...
Vjacheslav M. Prikhodko, A. N. Solovyev
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Mapping the Complexities of Online Dialogue: An Analytical Modeling Technique
Forum: Qualitative Social Research, 2014 The e-Dialogue platform was developed in 2001 to explore the potential of using the Internet for engaging diverse groups of people and multiple perspectives in substantive dialogue on sustainability.
Robert Newell, Ann Dale
doaj
Evaluation of the Increased Dynamic Effects on the Highway Bridge Superstructure
The Baltic Journal of Road and Bridge Engineering, 2018 Dynamic properties of the bridge superstructure vary depending on many characteristics of the bridge and the loading conditions. In this paper, maximum Dynamic Amplification Factor was calculated for six different types of typical pre-stressed concrete ...
Ilze Paeglite +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Current OncologyInterest in AYA cancer care has increased globally over the recent past; however, most of this work disproportionately represents white, heterosexual, middle-income, educated, and able-bodied people.
Tiffany T. Hill +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source