Results 41 to 50 of about 638,870 (367)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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The role of boundary and initial conditions for dynamical seasonal predictability [PDF]
Nonlinear Processes in Geophysics, 2003 The importance of initial state and boundary forcing for atmospheric predictability is explored on global to regional spatial scales and on daily to seasonal time scales.
T. J. Reichler, J. O. Roads
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
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Facts & FrictionsNews consumption and trust are shifting across generations as the structures of media production and distribution are reshaped by technology. In the past decade, the rise of algorithmically curated feeds, influencer commentary, and platform-specific news
Iman Kassam, Jaigris Hodson
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
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Seeds of Self-Determination: How Snuneymuxw Built Economic Power
Journal of Aboriginal Economic DevelopmentThis case study examines the development of the Petroglyph Development Group (PDG), the economic organization of the Snuneymuxw First Nation (SFN), tracing its growth from initial community-based ventures to larger undertakings such as the co-management
Greg Moynan, Tasha Brooks
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Frameworks and Models for Disseminating Curated Research Outcomes to the Public
SAGE Open, 2019 In our post-truth society, mobilizing “facts” and “evidence” has never been more important. We live in an age that is paradoxically information rich due to the proliferation of Internet Communication Technologies (ICTs) and information poor due to the ...
Jaime Clifton-Ross +2 more
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Manuscrito, 2020 Abstract Roads to Reference offers a highly valuable contribution to the theory of reference. The arguments in this book are quite convincing and the overall picture presented in it is quite attractive. In what follows I would like to present some critical comments regarding the first chapter of the book, Demonstratives and Conflicting Intentions.
openaire +4 more sources