Results 51 to 60 of about 3,704,322 (286)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Robot assisted Internal Mammary Artery detection for coronary revascularisation surgery [PDF]

, 2010
This paper presents a semi-automatic robotic system supporting a surgeon in the harvesting of the internal mammary artery (IMA) for an open chested intervention in coronary revascularisation surgery.
Vazquez, Adrian, Hirzinger, Gerd, Florian A Fröhlich, Passig, Georg, Georg Passig, Gerd Hirzinger, Adrian Vazquez, Fröhlich, Florian A.   +7 more
core   +1 more source

Clinical Practice Data of Robot-assisted Gait Therapy After Stroke: A Retrospective Study

Bagcilar Medical Bulletin, 2022
Objective:Patients with stroke are often exposed to significant levels of disability resulting in long-term functional limitations. Robot-assisted gait therapy in stroke rehabilitation is a novel modality for improving walking ability and balance.
İlknur Saral, Esra Tekeci, Yasemin Tuğçe Yayla, Engin Çakar   +3 more
doaj   +1 more source

Within- and between-therapist agreement on personalized parameters for robot-assisted gait therapy: the challenge of adjusting robotic assistance

Journal of NeuroEngineering and Rehabilitation, 2023
Abstract Background Stationary robotic gait trainers usually allow for adjustment of training parameters, including gait speed, body weight support and robotic assistance, to personalize therapy. Consequently, therapists personalize parameter settings to pursue a relevant therapy goal for each patient.
van Dellen, Florian, Aurich-Schuler, Tabea, Labruyère, Rob   +2 more
openaire   +5 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Abnormal synergistic gait mitigation in acute stroke using an innovative ankle–knee–hip interlimb humanoid robot: a preliminary randomized controlled trial

Scientific Reports, 2021
Abnormal spasticity and associated synergistic patterns are the most common neuromuscular impairments affecting ankle–knee–hip interlimb coordinated gait kinematics and kinetics in patients with hemiparetic stroke.
Chanhee Park, Mooyeon Oh-Park, Amy Bialek, Kathleen Friel, Dylan Edwards, Joshua Sung H. You   +5 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Social Stories in Robot-Assisted Therapy for Children With ASD

, 2017
Mobile technology devices are commonly used as assistive technology to support children with Autism Spectrum Disorder (ASD) in gaining skills in interpersonal communication. While considered generally safe and effective, there are concerns that a child that is taught to communicate through interactive technologies may become dependent on the virtual ...
Silvera-Tawil, D, Strnadova, I, Cumming, TM   +2 more
openaire   +2 more sources

Interactive Learning and Adaptation for Robot Assisted Therapy for People with Dementia [PDF]

Proceedings of the 9th ACM International Conference on PErvasive Technologies Related to Assistive Environments, 2016
In this paper, we present an adaptive cognitive music game designed to monitor and improve the attention levels of people with dementia. The goal of this game is to provide a customized protocol based on user needs and preferences, following the Reinforcement Learning (RL) framework.
Konstantinos Tsiakas, Cheryl Abellanoza, Fillia Makedon   +2 more
openaire   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source