Results 51 to 60 of about 256,885 (310)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2023 Presented on November 29, 2023 at 11:00 a.m. as a part of the IRIM Robotics Days for Industry 2023.Brad Range is a senior project manager at Intuitive Surgical with technical expertise in robotics, automation, medical devices, and consumer products ...
Range, Brad, Olivero, Daniel
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 2008 Most robots today can trace their origin to early industrial robot designs. Much of the technology that makes robots more human-friendly and adaptable for different applications has emerged from manufacturers of industrial robots.
Hägele, Martin, +3 more
core +2 more sources
Frontiers in Neurorobotics, 2010 Trying to understand human language by constructing robots that have language necessarily implies an embodied view of language, where the meaning of linguistic expressions is derived from the physical interactions of the organism with the environment. The paper describes a neural model of language according to which the robot's behaviour is controlled ...
openaire +5 more sources
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Autonomous Robots, 2006 [abstFig src='/00280002/01.jpg' width=""300"" text='A humanoid robot riding an excavator' ]The following article reviews past and current tendencies and derives and describes opportunities for construction robotics and automation. There substantial evidence in the construction industry, that conventional construction methodology has reached its limits.
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CoRR, 2020 Accepted paper of the AAAI 2020 Spring Symposium "Applied AI in Healthcare: Safety, Community, and the Environment" (Stanford University).
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Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source