Results 61 to 70 of about 258,399 (309)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Communications of the ACM, 2017 Healthcare robotics can provide health and wellness support to billions of people.
openaire +3 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Center for Occupational Robotics Research PPOP [2021] [PDF]
The National Institute for Occupational Safety and Health (NIOSH) Center for Occupational Robotics Research (CORR) addresses the safety of today\u2019s workers who use, wear, or work near robots.
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User-Friendly Robotics 2-Interfacing Robotics with any user [PDF]
, 2019 In this paper, the second part out of three, we continue presenting the route of our long experience in interfacing AI and Robotics with the public.
Lund, Henrik Hautop, Pagliarini, Luigi
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Software reconfiguration in robotics [PDF]
Robots often need to be reconfigurable-to customize, calibrate, or optimize robots operating in varying environments with different hardware. A particular challenge in robotics is the automated and dynamic reconfiguration to load and unload software ...
Pelliccione, Patrizio +7 more
core +1 more source
Developing a strategic research agenda for robotics in Europe [PDF]
, 2022 S.351-356Europe has a globally successful industrial robotics industry. Building on this is the next logical step for Europe to ensure that its robotics market share is maintained in industrial robots and elarged in the newly emerging application domains:
Bischoff, Rainer +2 more
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source