Results 151 to 160 of about 40,101 (290)
Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment
Advanced Science, EarlyView.This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao +17 morewiley +1 more sourceCD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of BiTE‐Secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity
Advanced Science, EarlyView.HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho +27 morewiley +1 more sourceMicroglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling
Advanced Science, EarlyView.Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang +17 morewiley +1 more sourceTrackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation
Advanced Science, EarlyView.We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie +14 morewiley +1 more sourceWednesday, 29 August 2012
, 2012 V. Salomaa, A. Havulinna, J. Kettunen, J. Eriksson, A. Jula, K. Kontula, C. Newton‐Cheh, M. Karakaš, J. Baumert, M. Kleber, B. Thorand, D. Dallmeier, W. Rottbauer, C. Meisinger, T. Illig, W. Maerz, W. Koenig, M. Musameh, W. Wang, C. Nelson, A. Balmforth, S. G. Ball, A. S. Hall, M. Tomaszewski, N. Samani, F. Beygui, P. Wild, T. Zeller, V. Truong, T. Munzel, G. Montalescot, D. Tregouet, F. Cambien, S. Blankenberg, L. Tiret, R. Caballero, L. Nuñez, A. Barana, P. Dolz-Gaitón, M. G. D. L. Fuente, I. Amorós, L. Monserrat, E. Delpón, A. Castro‐Beiras, J. Tamargo, N. Verweij, H. Mahmud, I. M. Leach, F. P. Brouwers, F. Asselbergs, R. Boer, H. Hillege, W. H. Gilst, H. Silljé, P. Harst, T. Kessler, Z. Aherrahrou, K. Schmidt, C. Wit, H. Schunkert, J. Erdmann, A. Antoniadis, Michail I. Papafaklis, Y. Chatzizisis, G. Sukhova, A. B. Baker, A. U. Coskun, S. Takahashi, E. Edelman, P. Stone, C. Feldman, C. Muhlen, D. Elverfeldt, K. Wiens, M. Meissner, A. Charles, K. Peter, C. Bode, J. Fabre, C. Roma-Lavisse, C. Zawadzki, M. Tagzirt, C. Banfi, S. Haulon, G. Chinetti-Gbaguidi, B. Jude, S. Susen, E. Belle, A. Dupont, R. Duivenvoorden, V. Mani, M. Woodward, D. Kallend, G. Suchánková, V. Fuster, J. Rudd, A. Tawakol, M. Farkouh, Z. Fayad, C. Gleißner, C. M. Helmes, C. Erbel, H. Katus, S. Lindberg, R. Møgelvang, S. Pedersen, M. Bjerre, J. Frystyk, A. Flyvbjerg, S. Galatius, J. Jensen, R. Simes, W. Hague, D. Espinoza, D. Sullivan, P. Glasziou, A. Keech, H. White, A. Tonkin, R. Boer, D. V. Veldhuisen, S. J. Bakker, R. Gansevoort, A. Kobold, K. Eggers, T. Kempf, L. Wallentin, K. Wollert, L. Lind, T. Brugger-Andersen, V. Ponitz, H. Staines, H. Grundt, O. Mjelva, R. Meling, D. W. Nilsen, F. Sofi, F. Cesari, A. Casini, C. Macchi, R. Abbate, G. Gensini, N. Okumura, T. Kondo, S. Osugi, K. Shimokata, K. Maeda, K. Matsushita, K. Yamashita, K. Matsudaira, T. Nagahiro, T. Murohara, C. Hsu, H. Leu, S. Lin, J. W. Chen, E. Smirnova, S. Yakushin, A. Vorobyev, C. Liakos, G. Vyssoulis, E. Karpanou, S. Kyvelou, V. Tzamou, A. Michaelides, A. Triantafyllou, P. Spanos, C. Stefanadis, M. Eto, T. Aonuma, M. Okayama, M. Kumada, R. Uehara, Y. Nakamura, E. Kajii, D. Terentes-Printzios, C. Vlachopoulos, K. Aznaouridis, N. Ioakeimidis, A. Synodinos, A. Aggelakas, M. Abdelrasoul, D. Kardara, N. Khuseyinova, P. Mueller, A. Schulz, R. Schnabel, C. Espinola-Klein, K. Lackner, T. Muenzel, B. E. Bussink, A. Holst, L. Jespersen, J. Deckers, G. Jensen, E. Prescott, N. Danchin, A. Battler, H. Bueno, C. Hamm, K. Fox, B. Lindhal, F. Schiele, M. Tendera, M. Tubaro, C. Vrints, G. Savarese, M. Volpe, F. Musella, L. Casaretti, P. Perrone-filardi, D. Rothenbacher, H. Brenner, I. Čeponienė, K. Kotseva, D. Wood, R. Ferrari, K. Fox, M. Bertrand, J. Mourad, K. Akkerhuis, L. Vark, E. Boersma, M. Cuchel, Z. W. Chen, J. Qian, J. Y. Ma, J. Ge, Y. Nishihata, Y. Takata, K. Kato, K. Shiina, Y. Usui, A. Yamashina, R. Marcucci, A. Gori, C. Burgisser, S. Francini, F. Fattirolli, E. Toda, G. Lip, S. Uchiyama, K. Shimada, H. Origasa, H. Kobayashi, A. Kawamura, K. Kitagawa, Y. Ikeda, S. Goto, P. Jousilahti, Y. Wang, G. Hu, J. Tuomilehto, R. Antikainen, J. Scholl, M. Schneider, H. Kaelsch, M. H. Berg, N. Lehmann, A. Mahabadi, K. Kara, S. Moehlenkamp, N. Dragano, S. Moebus, K. Joeckel, R. Erbel, R. Stewart, C. Held, R. Brown, O. Vedin, E. Hagstrom, J. Soffer, R. Davies, T. Moholdt, B. Nes, U. Wisløff, C. Werner, M. Hauser, K. Schirra, T. Meyer, M. Boehm, U. Laufs, A. Roncella, C. Pristipino, C. Cianfrocca, V. Pasceri, D. Irini, S. Scorza, A. Varveri, J. Denollet, S. Pedersen, G. Speciale, M. Liljeroos, S. Agren, T. Jaarsma, K. Årestedt, A. Stromberg, F. Capuano, G. Derumeaux, C. Gardel, M. Couralet, J. Thébaut, A. Desplanques-Leperre, C. Grenier, R. L. Moign, K. Laut, T. Lash, S. D. Kristensen, J. Ball, M. Carrington, S. Stewart, A. Rajamanickam, Y. Zhang, C. Jurkovitz, R. Aguiar, X. Xu, A. Disabatino, W. Weintraub, E. Rahman, G. Vilahur, L. Casaní, O. Babot, J. Guerra, L. Badimón, A. Heinen, F. Behmenburg, I. Bauer, M. Hollmann, R. Huhn, D. Morin, S. Nunes-Figueiredo, S. Schaller, R. Pruss, A. Berdeaux, A. Akhmedov, V. Braunersreuther, F. Montecucco, P. Jakob, G. Camici, F. Mach, T. Luescher, T. Soeki, S. Bando, T. Niki, K. Yamaguchi, Y. Taketani, T. Iwase, H. Yamada, T. Wakatsuki, K. Kangawa, M. Sata, A. Yoshida, S. Sanada, H. Asanuma, H. Sasaki, H. Takahama, M. Asakura, T. Yoshitomi, Y. Nagasaki, M. Kitakaze, M. Hochadel, N. Meneveau, W. Wojakowski, M. Gierlotka, J. Bassand, A. Gitt, S. Bangalore, A. Breazna, D. Demicco, F. Messerli, R. Sakurai, T. Hoshi, A. Sato, D. Abé, Y. Kakefuda, T. Harunari, E. Ojima, D. Hiraya, H. Watabe, N. Takeyasu, K. Aonuma, Z. Sergie, U. Baber, A. Chieffo, S. Sartori, D. Cohen, C. Gibson, G. Weisz, B. Witzenbichler, A. Colombo, R. Mehran, E. Rapsomaniki, A. Shah, S. Denaxas, O. Nicholas, A. Hingorani, G. Feder, A. Timmis, H. Hemingway, Y. Takagi, J. Takahashi, S. Yasuda, Y. Ogata, T. Sumiyoshi, T. Goto, Y. Tanabe, S. Sueda, H. Ogawa, H. Shimokawa, F. Towae, C. Juenger, A. Papp, R. Zahn, U. Zeymer, J. Senges, A. Schoenenberger, S. Felber, S. Gujer, A. Moser, P. Jamshidi, A. Stuck, P. Erne, M. Milo, R. Nerla, P. Tarzia, F. Infusino, A. Sestito, I. Battipaglia, A. Stazi, G. Scalone, G. Lanza, F. Crea, C. M. Patterson, N. Ahmed, E. Nicol, L. Bryan, D. Bell, C. Wunderlich, M. Forkmann, S. Kolschmann, K. Ibrahim, M. Christoph, L. Holzhauser, A. Schmeisser, J. Fuhrmann, A. Boscheri, R. Strasser, K. Russell, M. Eriksen, J. Fjeld, S. Savari, T. Edvardsen, O. Smiseth, A. Puzzovivo, M. Iacoviello, C. Forleo, I. Nalin, P. Guida, F. Monitillo, M. S. Lattarulo, V. Marangelli, S. Favale, U. Hoke, D. Auger, D. Leong, E. Holman, M. Schalij, J. Bax, N. Marsan, V. Delgado, H. Sabbah, M. Wang, R. Gupta, S. Rastogi, M. Sabbah, B. Albrecht-Kupper, W. Abraham, P. Adamson, N. Raval, L. Stevenson, J. Bauman, S. Neville, P. Cowart, J. Henderson, G. Ginn, J. Yadav, M. Lavilla, E. S. Martinez, D. Arnau, M. Enriquez, R. C. Rofes, M. Olle, I. Hernanz, F. Pérez-Villa, R. Ushijima, S. Joho, Y. Oda, T. Hirai, H. Inoue, A. Gkouziouta +499 moresemanticscholar +1 more sourceIlluminating Mitochondrial RNA G‐Quadruplexes as Structural Brakes on RNA Granule Assembly and OXPHOS
Advanced Science, EarlyView.A new fluorescent probe, MitoQUMA, brings mitochondrial RNA G‐quadruplexes (mtRNA G4s) into view in live cells. This tool reveals that excessive mtRNA G4 formation halts mitochondrial RNA granule (MRG) assembly, opposite to the phase‐separation role of cytoplasmic RNA G4s. A chemical genetic screen further identifies a Wnt/β‐catenin–GRSF1–mtRNA G4 axis Gui‐Xue Tang, Jia‐Tong Yan, Mao‐Lin Li, Cui Zhou, Jian Wang, Shuo‐Bin Chen, Zhi‐Shu Huang, Jia‐Heng Tan +7 morewiley +1 more sourceProgramming Next‐Generation Synthetic Biosensors by Genetic Circuit Design
Advanced Science, EarlyView.Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...Yuanli Gao, Cheng Huang, Jiaxuan Deng, Lei Wang, Baojun Wang +4 morewiley +1 more source
