From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Robust Optimal Design of SPMSM Considering Manufacturing Tolerances of Permanent Magnets
Servo motors are widely used in systems that require high speed, high precision, and accurate position control. One of the critical aspects of servo motor design is the minimization of cogging torque to reduce motor vibration and noise.
Jae-Hyeon Yeo, Jun-Kyu Kang, Jin Hur
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Design and assessment of a multiple sensor fault tolerant robust control system [PDF]
This paper presents an enhanced robust control design structure to realise fault tolerance towards sensor faults suitable for multi-input-multi-output (MIMO) systems implementation.
Chen, J +5 more
core +1 more source
A New Nozzle for Continuous Inkjet Printers
The shape of a nozzle for high-quality printing was optimized by using a standard, robust design method, and a method for fabricating the optimized nozzle was established.
Mamoru OKANO +4 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Robust Design of a Dimethyl Ether Production Process Using Process Simulation and Robust Bayesian Optimization. [PDF]
Nakayama Y, Kaneko H.
europepmc +1 more source
Robust multivariable feedback design
A primary role of feedback design is to enable a system to cope with the inevitable uncertainly associated with its description. Although it is often the case that we have at hand a practical description of both the size and structure of the expected uncertainty, simple multivariable design strategies which effectively incorporate this information have
Kouvaritakis, B, Trimboli, M
openaire +1 more source

