Results 91 to 100 of about 3,261,710 (304)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Robust PI Controller Design Satisfying Sensitivity and Uncertainty Specifications [PDF]
, 2003 This paper presents a control design method for determining proportional-integral-type controllers satisfying specifications on gain margin, phase margin, and an upper bound on the (complementary) sensitivity for a finite set of plants.
Nagurka, Mark L., Yaniv, O.
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018 The robust design optimization (RDO) problem is generally formulated as a weighted sum of the nominal objective function and the robust term. In the RDO problem, a deterministic optimum design is regarded as one of the local optima.
Makoto ITO, Nozomu KOGISO, Taku HASEGAWA
doaj +1 more source
A robust design methodology suitable for application to one-off products [PDF]
, 1998 Robust design is an activity of fundamental importance when designing large, complex, one-off engineering products. Work is described which is concerned with the application of the theory of design of experiments and stochastic optimization methods to ...
COATES G. +5 more
core +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Robust aerodynamic design of variable speed wind turbine rotors [PDF]
, 2012 This study focuses on the robust aerodynamic design of the bladed rotor of small horizontal axis wind turbines. The optimization process also considers the effects of manufacturing and assembly tolerances on the yearly energy production.
Campobasso, Michele Sergio +2 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
MachinesTo address the stringent emission regulations of the International Maritime Organization (IMO) and the growing demand for green port operations, this study proposes an innovative range-extended series hybrid powertrain system featuring a dedicated ...
Zhao Li, Hua Tian, Wuqiang Long
doaj +1 more source
Robust Design Optimization for Egressing Pedestrians in Unknown Environments
, 2019 In this paper, we deal with a size-variable group of pedestrians moving in a unknown confined environment and searching for an exit. Pedestrian dynamics are simulated by means of a recently introduced microscopic (agent-based) model, characterized by an ...
Cristiani, Emiliano, Peri, Daniele
core +1 more source