Results 111 to 120 of about 11,839,721 (284)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Robust Design Based on Fuzzy Optimization
, 2015 [[abstract]]In this paper, we present the problem of robust design under the fuzzy environment. By defining the linear membership functions for relaxing the conditions on the process mean and variance, we can adopt the minimum criterion for aggregating ...
Chung-Ho Chen, 陳忠和
core
A Robust Design-Based Expert System for Feature Selection and COVID-19 Pandemic Prediction in Japan. [PDF]
Healthcare (Basel), 2022 Ho CT, Wang CY.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Fault Tree Analysis for Robust Design
DesignsThe objective of this research is to incorporate system failure into a robust design formation and solution process. The system failure referred to here will be built using fault tree analysis (FTA), which will take all lower-level failure events into ...
Jonathan DeGroff, Gene Jean-Win Hou
doaj +1 more source
Proceedings of the 26th ACM Conference on Economics and ComputationWe study procurement design when the buyer is uncertain about both the value of the good and the seller's cost. The buyer has a conjectured model but does not fully trust it. She first identifies mechanisms that maximize her worst-case payoff over a set of plausible models, and then selects one from this set that maximizes her expected payoff under the
Debasis Mishra +2 more
openaire +3 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
IEEE AccessMost electrical machine design optimization processes do not include constraints imposed during manufacture. Ignoring cutting tolerance when optimizing a machine, for example, can result in a machine who’s performance is susceptible to ...
Farshid Mahmouditabar, Nick J. Baker
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Robust design of a green-responsive closed-loop supply chain network for the ventilator device. [PDF]
Environ Sci Pollut Res Int, 2022 Asadi Z, Khatir MV, Rahimi M.
europepmc +1 more source