Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Utilizing Robust Design to Optimize Composite Bioadhesive for Promoting Dermal Wound Repair. [PDF]
Polymers (Basel), 2023 Pinnaratip R +6 more
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Robust design of a machine learning-based GNSS NLOS detector with multi-frequency features. [PDF]
Front Robot AI, 2023 García Crespillo O +3 more
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
New heuristic-based design of robust power system stabilizers
, 2004 This paper proposes a new robust design of power system stabilizers (PSSs) in a multimachine power system using a heuristic optimization method. The structure of each PSS used is similar to that of a conventional lead/lag stabilizer.
Tippayachai, Jarurote +5 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Robustness Design of LLC Resonant Converter
Kongzhi Yu Xinxi Jishu, 2019 Setting a reasonable dead time is an important condition to ensure that ZVS type LLC converters achieve soft switch. In practical engineering, parameters of the resonant tank components will fluctuate due to the dispersion of processing technology, the ...
TANG Juan, RAO Peinan, XIE Wei, CHEN Si
doaj
Robust design of a logistics system using FePIA procedure and analysis of trade-offs between CO2 emissions and net present value. [PDF]
Heliyon, 2023 Roa AP, Escobar JW, Montoya MP.
europepmc +1 more source