Results 101 to 110 of about 3,216,313 (259)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Design optimization for cost and quality: The robust design approach [PDF]

Designing reliable, low cost, and operable space systems has become the key to future space operations. Designing high quality space systems at low cost is an economic and technological challenge to the designer.
Unal, Resit
core   +1 more source

A Powerful Optimization Tool for Analog Integrated Circuits Design [PDF]

, 2013
This paper presents a new optimization tool for analog circuit design. Proposed tool is based on the robust version of the differential evolution optimization method. Corners of technology, temperature, voltage and current supplies are taken into account
Jakovenko, J., Kubar, M.
core   +1 more source

Algorithm Engineering in Robust Optimization

, 2015
Robust optimization is a young and emerging field of research having received a considerable increase of interest over the last decade. In this paper, we argue that the the algorithm engineering methodology fits very well to the field of robust ...
A Agra, A Atamtürk, A Beck, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Erera, A Kasperski, A Kasperski, A Kasperski, A Kasperski, A Mutapcic, A Ouorou, A Sbihi, A Schöbel, A Soyster, A Takeda, AB Chassein, B Roy, C Bohle, C Büsing, C Büsing, C Liebchen, D Bertsimas, D Bertsimas, D Bertsimas, D Bertsimas, D Bertsimas, D Bertsimas, D Bertsimas, D Bertsimas, D Catanzaro, D Delling, D Golovin, DJ Alem, DJ Thuente, E Conde, E Conde, E Conde, E Conde, F Bruns, F Pérez-Galarce, F Taniguchi, G Calafiore, G Calafiore, GC Calafiore, H Aissi, H Aissi, H Iida, H Mausser, H Yaman, HE Mausser, I Averbakh, I Averbakh, J Goh, J Lin, J Löfberg, J Pereira, J Xu, JE Falk, JLG Velarde, JM Mulvey, JR Farias de, KS Goetzmann, L Jenkins, LE Ghaoui, M Bürger, M Fischetti, M Fischetti, M Fischetti, M Goerigk, M Goerigk, M Goerigk, M Goerigk, M Goerigk, M Goerigk, M Goerigk, M Goerigk, M Goerigk, M Inuiguchi, M López, M Monaci, M Monaci, MC Campi, MK Zanjani, N Eggenberg, O Berman, P Adasme, P Kouvelis, P Sanders, P Zieliński, PC Bouman, R Kalai, R Khandekar, R Montemanni, R Montemanni, R Montemanni, R Reemtsen, S Cicerone, S Siddiqui, S Suzuki, TS Ng, U Feige, V Cacchiani, V Jeyakumar, X Song, Y Nikulin, Y Yin   +114 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Robust design optimization using the price of robustness, robust least squares and regularization methods

International Journal for Simulation and Multidisciplinary Design Optimization, 2017
In this paper a framework for robust optimization of mechanical design problems and process systems that have parametric uncertainty is presented using three different approaches.
Bukhari Hassan J.
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Designing robust feedback linearisation controllers using imperfect dynamic models and sensor feedback

Cogent Engineering, 2016
The paper considers key limitation of the feedback linearisation controller designed for nonlinear systems based on the imperfect nominal dynamics model and sensors. The model-reality differences cause signal leakages in the feedback linearised dynamics.
Yongjing Wang, Lu Wang, Mietek A. Brdys
doaj   +1 more source

Robust Design of a Dimethyl Ether Production Process Using Process Simulation and Robust Bayesian Optimization. [PDF]

ACS Omega, 2023
Nakayama Y, Kaneko H.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source