Results 111 to 120 of about 3,179,683 (287)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Multi-disciplinary robust design of variable speed wind turbines [PDF]

, 2011
This paper addresses the preliminary robust multi-disciplinary design of small wind turbines. The turbine to be designed is assumed to be connected to the grid by means of power electronic converters.
Campobasso, Michele Sergio, Dellantonio, Michele, Minisci, Edmondo, Montecucco, Andrea, Vasile, Massimiliano   +4 more
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Robust Design of a Dimethyl Ether Production Process Using Process Simulation and Robust Bayesian Optimization. [PDF]

ACS Omega, 2023
Nakayama Y, Kaneko H.
europepmc   +1 more source

Robust designs in non-inferiority three arm clinical trials with presence of heteroscedasticity [PDF]

In this paper, we describe an adjusted method to facilitate a non-inferiority trial by a three-arm robust design. Because local optimal designs derived in Hasler et al.
Dette, Holger, Hothorn, Ludwig A., Trampisch, Matthias   +2 more
core  

Learning-based predictive control for linear systems: a unitary approach

, 2018
A comprehensive approach addressing identification and control for learningbased Model Predictive Control (MPC) for linear systems is presented. The design technique yields a data-driven MPC law, based on a dataset collected from the working plant.
Fagiano, Lorenzo, Farina, Marcello, Scattolini, Riccardo, Terzi, Enrico   +3 more
core   +1 more source

Robust System Design

IPSJ Transactions on System LSI Design Methodology, 2011
Robust system design is essential to ensure that future electronic systems perform correctly despite rising complexity and increasing disturbances. In contrast, today's mainstream systems typically assume that transistors and interconnects operate correctly over their useful lifetime.
Subhasish Mitra, Hyungmin Cho, Ted Hong, Young Moon Kim, Hsiao-Heng Kelin Lee, Larkhoon Leem, Yanjing Li, David Lin, Evelyn Mintarno, Diana Mui, Sung-Boem Park, Nishant Patil, Hai Wei, Jie Zhang   +13 more
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Robust pareto multiobjective optimum design of FG-Beam under moving mass [PDF]

Computational Algorithms and Numerical Dimensions
The optimal selection of Functionally Graded Material (FGM) materials profiles, with regard to cost functions such as weight and stress, is an important issue in the optimization field.
Moein Abdollah-Salimi, Nader Nariman-Zadeh, Reza Ansari   +2 more
doaj   +1 more source

Utilizing Robust Design to Optimize Composite Bioadhesive for Promoting Dermal Wound Repair. [PDF]

Polymers (Basel), 2023
Pinnaratip R, Zhang Z, Smies A, Forooshani PK, Tang X, Rajachar RM, Lee BP.   +6 more
europepmc   +1 more source