Results 101 to 110 of about 376,109 (314)
Portfolio optimization with pw-robustness
EURO Journal on Computational Optimization, 2018 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Virginie Gabrel +2 more
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Robust Optimization Utilizing the Second-order Design Sensitivity Information
, 2009 This paper presents an effective methodology for robust optimization of electromagnetic devices. To achieve the goal, the method improves the robustness of the objective function by minimizing the second-order sensitivity information, called a gradient ...
Kim, Dong-Wook +4 more
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Quantitative Stability Analysis in Distributionally Robust Optimization
, 2018 Ambiguity set is a key element in distributionally robust optimization models. Here we investigate the impact of perturbation of ambiguity set on the optimal value and the optimal solutions. We consider the case where the ambiguity set is defined through
Xu, Huifu
core
Deterministic and Robust Optimization Approach for Single Artillery Unit Fire Scheduling Problem
Applied Sciences, 2017 In this study, deterministic and robust optimization models for single artillery unit fire scheduling are developed to minimize the total enemy threat to friendly forces by considering the enemy target threat level, enemy target destruction time, and ...
Yong Baek Choi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
A Tractable Format for Distributionally Robust Optimization
, 2019 We present a unified and tractable framework for distributionally robust optimization that could encompass a variety of statistical information including, among others things, constraints on expectation, scenario-wise expectations, Wasserstein metric ...
Sim, Melvyn
core
Robust Optimization of a MEMS Accelerometer Considering Temperature Variations
Sensors, 2015 A robust optimization approach for a MEMS accelerometer to minimize the effects of temperature variations is presented. The mathematical model of the accelerometer is built.
Guangjun Liu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source