Results 81 to 90 of about 1,105,335 (289)

Robust Optimization of Signal Control Parameters for Unsaturated Intersection Based on Tabu Search-Artificial Bee Colony Algorithm

IEEE Access, 2018
In order to overcome the drawback of the conventional signal timing optimization, a robust optimization algorithm for signal control parameters based on Tabu search-artificial bee colony algorithm is proposed under unsaturated flow condition.
Wei Hao, Changxi Ma, Bahman Moghimi, Yuanyuan Fan, Zhibo Gao   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Robust Approximate Optimality Conditions for Uncertain Nonsmooth Optimization with Infinite Number of Constraints

Mathematics, 2018
This paper deals with robust quasi approximate optimal solutions for a nonsmooth semi-infinite optimization problems with uncertainty data. By virtue of the epigraphs of the conjugates of the constraint functions, we first introduce a robust type closed ...
Xiangkai Sun, Hongyong Fu, Jing Zeng
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Efficient Robust Optimization of Metal Forming Processes using a Sequential Metamodel Based Strategy [PDF]

, 2011
The coupling of Finite Element (FE) simulations to mathematical optimization techniques has contributed significantly to product improvements and cost reductions in the metal forming industries.
Boogaard, A.H. van den, Klaseboer, G., Wiebenga, J.H.   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Differential Evolution in Robust Optimization Over Time Using a Survival Time Approach

Mathematical and Computational Applications, 2020
This study presents an empirical comparison of the standard differential evolution (DE) against three random sampling methods to solve robust optimization over time problems with a survival time approach to analyze its viability and performance capacity ...
José-Yaír Guzmán-Gaspar, Efrén Mezura-Montes, Saúl Domínguez-Isidro   +2 more
doaj   +1 more source

Adversarially Robust Optimization with Gaussian Processes [PDF]

, 2018
In this paper, we consider the problem of Gaussian process (GP) optimization with an added robustness requirement: The returned point may be perturbed by an adversary, and we require the function value to remain as high as possible even after this ...
Bogunovic, Ilija, Cevher, Volkan, Jegelka, Stefanie, Scarlett, Jonathan   +3 more
core   +1 more source

Algorithm Engineering in Robust Optimization

, 2015
Robust optimization is a young and emerging field of research having received a considerable increase of interest over the last decade. In this paper, we argue that the the algorithm engineering methodology fits very well to the field of robust ...
A Agra, A Atamtürk, A Beck, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Ben-Tal, A Erera, A Kasperski, A Kasperski, A Kasperski, A Kasperski, A Mutapcic, A Ouorou, A Sbihi, A Schöbel, A Soyster, A Takeda, AB Chassein, B Roy, C Bohle, C Büsing, C Büsing, C Liebchen, D Bertsimas, D Bertsimas, D Bertsimas, D Bertsimas, D Bertsimas, D Bertsimas, D Bertsimas, D Bertsimas, D Catanzaro, D Delling, D Golovin, DJ Alem, DJ Thuente, E Conde, E Conde, E Conde, E Conde, F Bruns, F Pérez-Galarce, F Taniguchi, G Calafiore, G Calafiore, GC Calafiore, H Aissi, H Aissi, H Iida, H Mausser, H Yaman, HE Mausser, I Averbakh, I Averbakh, J Goh, J Lin, J Löfberg, J Pereira, J Xu, JE Falk, JLG Velarde, JM Mulvey, JR Farias de, KS Goetzmann, L Jenkins, LE Ghaoui, M Bürger, M Fischetti, M Fischetti, M Fischetti, M Goerigk, M Goerigk, M Goerigk, M Goerigk, M Goerigk, M Goerigk, M Goerigk, M Goerigk, M Goerigk, M Inuiguchi, M López, M Monaci, M Monaci, MC Campi, MK Zanjani, N Eggenberg, O Berman, P Adasme, P Kouvelis, P Sanders, P Zieliński, PC Bouman, R Kalai, R Khandekar, R Montemanni, R Montemanni, R Montemanni, R Reemtsen, S Cicerone, S Siddiqui, S Suzuki, TS Ng, U Feige, V Cacchiani, V Jeyakumar, X Song, Y Nikulin, Y Yin   +114 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source