Results 81 to 90 of about 376,109 (314)
IEEE Access, 2018 In order to overcome the drawback of the conventional signal timing optimization, a robust optimization algorithm for signal control parameters based on Tabu search-artificial bee colony algorithm is proposed under unsaturated flow condition.
Wei Hao +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Robust Optimization of Currency Portfolios [PDF]
We study a currency investment strategy, where we maximize the return on a portfolio of foreign currencies relative to any appreciation of the corresponding foreign exchange rates. Given the uncertainty in the estimation of the future currency values, we
Berc Rustem +3 more
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Differential Evolution in Robust Optimization Over Time Using a Survival Time Approach
Mathematical and Computational Applications, 2020 This study presents an empirical comparison of the standard differential evolution (DE) against three random sampling methods to solve robust optimization over time problems with a survival time approach to analyze its viability and performance capacity ...
José-Yaír Guzmán-Gaspar +2 more
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Mathematics, 2018 This paper deals with robust quasi approximate optimal solutions for a nonsmooth semi-infinite optimization problems with uncertainty data. By virtue of the epigraphs of the conjugates of the constraint functions, we first introduce a robust type closed ...
Xiangkai Sun, Hongyong Fu, Jing Zeng
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Robust Portfolio Optimization with a Hybrid Heuristic Algorithm [PDF]
Estimation errors in both the expected returns and the covariance matrix hamper the constructing of reliable portfolios within the Markowitz framework. Robust techniques that incorporate the uncertainty about the unknown parameters are suggested in the ...
Peter Winker, Björn Fastrich
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, 2007 The well-known quality improvement methodology, robust design, is a powerful and cost-effective technique for building quality into the design of products and processes.
Antony, Jiju +2 more
core +1 more source