Results 61 to 70 of about 1,105,335 (289)

Robust Topology Optimization for Compliant Mechanisms Considering Uncertainty of Applied Loads

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2008
In this study, a robust topology optimization method is proposed for compliant mechanisms, where the effect that variation of the input load direction has on the output displacement is considered.
Nozomu KOGISO   +4 more
doaj   +1 more source

Robust optimization with incremental recourse [PDF]

open access: yes, 2013
In this paper, we consider an adaptive approach to address optimization problems with uncertain cost parameters. Here, the decision maker selects an initial decision, observes the realization of the uncertain cost parameters, and then is permitted to ...
Nasrabadi, Ebrahim, Orlin, James B.
core  

Multicriteria adjustable robustness

open access: yesResults in Applied Mathematics
Multicriteria adjustable robust optimization (MARO) problems are highly relevant for a wide variety of practical problems with a two-stage-decision, typically an initial purchase decision followed by the possibility to react during operation after ...
Elisabeth Halser   +5 more
doaj   +1 more source

A robust optimization method based on previous optimization knowledge

open access: yesZhongguo Jianchuan Yanjiu, 2022
ObjectivesAs solving the robust optimization (RO) problem with interval uncertainty is unduly time-consuming when the nested differential evolution algorithm is directly used, a new RO design method is proposed.MethodsIn the proposed method, individuals'
Guochen LYU   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Analysis-of-marginal-Tail-Means (ATM): a robust method for discrete black-box optimization

open access: yes, 2018
We present a new method, called Analysis-of-marginal-Tail-Means (ATM), for effective robust optimization of discrete black-box problems. ATM has important applications to many real-world engineering problems (e.g., manufacturing optimization, product ...
Mak, Simon, Wu, C. F. Jeff
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Robust Phase Unwrapping by Convex Optimization

open access: yes, 2014
The 2-D phase unwrapping problem aims at retrieving a "phase" image from its modulo $2\pi$ observations. Many applications, such as interferometry or synthetic aperture radar imaging, are concerned by this problem since they proceed by recording complex ...
Gonzalez, Adriana, Jacques, Laurent
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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