Results 51 to 60 of about 315,736 (266)

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Robust Covariance Matrix Adaptation Evolution Strategy: Optimal Design of Magnetic Devices Considering Material Variation

IEEE Access, 2023
Uncertainties caused by material variation can significantly impair the characteristics of devices. Therefore, it is important to design devices whose performance is not significantly damaged even when material variations occur. Robust optimization seeks
Akito Maruo, Hajime Igarashi
doaj   +1 more source

Mean robust optimization

Mathematical Programming
Robust optimization is a tractable and expressive technique for decision-making under uncertainty, but it can lead to overly conservative decisions when pessimistic assumptions are made on the uncertain parameters. Wasserstein distributionally robust optimization can reduce conservatism by being data-driven, but it often leads to very large problems ...
I. Wang (Irina), C. Becker (Cole), BPG van Parys (Bart), B. Stellato (Bartolomeo)   +3 more
openaire   +4 more sources

Robust optimization ? methodology and applications [PDF]

Mathematical Programming, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Aharon Ben-Tal, Arkadi Nemirovski
openaire   +2 more sources

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Reducing Conservatism in Robust Optimization [PDF]

INFORMS Journal on Computing, 2020
Summary: Although robust optimization is a powerful technique in dealing with uncertainty in optimization, its solutions can be too conservative. More specifically, it can lead to an objective value much worse than the nominal solution or even to infeasibility of the robust problem.
Ernst Roos, Dick den Hertog
openaire   +3 more sources

Heterogeneous-Objective Robust Optimization of Complex Mechatronic Components Considering Interval Uncertainties

IEEE Access, 2019
Structural optimization of complex mechatronic components may involve heterogeneous competing performance indices, including the cost, fixation, benefit, and deviation ones.
Jin Cheng, Yangming Qian, Zhenyu Liu, Yixiong Feng, Zhendong Zhou, Jianrong Tan   +5 more
doaj   +1 more source

A robust optimization method based on previous optimization knowledge

Zhongguo Jianchuan Yanjiu, 2022
ObjectivesAs solving the robust optimization (RO) problem with interval uncertainty is unduly time-consuming when the nested differential evolution algorithm is directly used, a new RO design method is proposed.MethodsIn the proposed method, individuals'
Guochen LYU, Yuansheng CHENG, Jiaxiang YI, Jun LIU   +3 more
doaj   +1 more source

Robust Optimization of Credit Portfolios [PDF]

Mathematics of Operations Research, 2017
We introduce a dynamic credit portfolio framework where optimal investment strategies are robust against misspecifications of the reference credit model. The risk-averse investor models his fear of credit risk misspecification by considering a set of plausible alternatives whose expected log likelihood ratios are penalized.
Lijun Bo, Agostino Capponi
openaire   +3 more sources