Results 91 to 100 of about 1,637,129 (288)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Iteratively Reweighted Blind Deconvolution With Adaptive Regularization Parameter Estimation
IEEE Access, 2017 In many realistic image processing applications, the acquired images often suffer from mixed noises and blurring, which greatly degrade the image quality.
Houzhang Fang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Revstat Statistical Journal, 2007 We consider the problem of identifying multiple outliers in linear regression models. We propose a penalized trimmed squares (PTS) estimator, where penalty costs for discarding outliers are inserted into the loss function.
G. Zioutas +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Robust Regularized Kernel Regression
IEEE Transactions on Systems, Man, and Cybernetics, Part B (Cybernetics), 2008 Robust regression techniques are critical to fitting data with noise in real-world applications. Most previous work of robust kernel regression is usually formulated into a dual form, which is then solved by some quadratic program solver consequently.
Jianke Zhu +2 more
openaire +4 more sources
Financial structure gap and economic development in India
Journal of Business Economics and Management, 2014 This study is built on the concept of optimal financial structure and examines its dynamics with the economic development process of India. Specifically, the present study intends to examine the evolving importance of banks and markets during different ...
Pradeepta Sethi, Brajesh Kumar
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Heteroskedasticity-Robust Tests in Regression Directions [PDF]
We develop simple procedures to test for omitted variables and perform other tests in regression directions, which are asymptotically valid in the presence of heteroskedasticity of unknown form. We examine the asymptotic behaviour of these tests, and use
James G. MacKinnon, Russell Davidson
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source