Results 81 to 90 of about 672,236 (262)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Nexus Between Artificial Intelligence, Renewable Energy, and Economic Development: A Multi-Method Approach

Economies
Artificial intelligence (AI) is a key driver of the energy transition and sustainable economic development. However, the specific mechanisms through which AI adoption impacts renewable energy production versus consumption remain poorly understood.
Laura Vasilescu, Mirela Sichigea, Cătălina Sitnikov, Laurențiu-Stelian Mihai   +3 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

The Contrasting Ecological Effects of Farmland and Alfalfa Grassland Across Different Planting Scales in the North China Plain

Agronomy
Purpose: Comparing farmland and alfalfa grassland systems under different planting scales in influencing grain yield and environmental security is crucial to achieving sustainable food development. This study aims to evaluate the environmental impacts of
Xiaoyu Zhu, Yutong Li, Zhongkuan Liu, Changliang Shao, Lulu Wang, Xiaoping Xin   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Application of robust regression in translational neuroscience studies with non-Gaussian outcome data. [PDF]

Front Aging Neurosci, 2023
Malek-Ahmadi M, Ginsberg SD, Alldred MJ, Counts SE, Ikonomovic MD, Abrahamson EE, Perez SE, Mufson EJ.   +7 more
europepmc   +1 more source

Robust Ordinal Regression

, 2014
Any multiple Criteria Decision Aiding (MCDA) method needs some preference parameters. The Decision Maker (DM) could be asked to provide directly all these parameters; however, because it needs a great cognitive effort, the indirect preference information is more used in practice. Starting from the indirect preference information, usually there could be
Corrente S, GRECO, Salvatore, Kadziński M, Słowiński R.   +3 more
openaire   +3 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

GB-SAR Engineering Interference Suppression Method Integrating Amplitude-Phase Feature Analysis and Robust Regression

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Complex construction environments can interfere with ground-based synthetic aperture radar (GB-SAR) deformation monitoring, potentially leading to missed or false alarms.
Wenting Zhang, Tao Lai, Yuanhui Mo, Haifeng Huang, Qingsong Wang, Zhihua Zhou   +5 more
doaj   +1 more source

RegCloser: a robust regression approach to closing genome gaps. [PDF]

BMC Bioinformatics, 2023
Cao S, Li M, Li LM.
europepmc   +1 more source