Results 51 to 60 of about 672,236 (262)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Nonparametric Functional Times Series Data Analysis by kNN–Local Linear M-Regression

Mathematics
This paper addresses the problem of nonparametric regression for functional time series, a setting complicated by the infinite-dimensional nature of the covariates, temporal dependence, and potential for outliers.
Salim Bouzebda, Mohammed B. Alamari, Fatimah A. Almulhim, Ali Laksaci   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Robust and Non-Parametric Regression Estimators for Predictive Mean Estimation in Stratified Sampling

Axioms
In modern survey sampling, particularly when using stratified random sampling (StRS), the existence of outliers and model mis-specifications is a daunting challenge to the conventional parametric and nonparametric methods of estimating parameters.
Rashid Mahmood, Huda M. Alshanbari, Nasir Ali, Muhammad Hanif   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Quantification of Microplastics in Treated Drinking Water Using µ-FT-IR Spectroscopy: A Case Study from Northeast Italy

Microplastics
Microplastics spread through the environment in various ways. Inland waters are an ideal medium for their dispersal, as they collect pollutants from various sources and transport them over long distances.
Giulia Dalla Fontana, Davide Lamprillo, Francesca Dotti, Ada Ferri, Tommaso Foccardi, Raffaella Mossotti   +5 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Bridging Prosperity: Unravelling the Interplay of Public Borrowing, Gross Capital Formation, and Economic Growth In The Nepalese Economy

Financial Internet Quarterly
This study investigates the impact of public borrowing and total capital formation on Nepal’s economic growth. The analysis relies on secondary data from publications from the Nepal Rastra Bank and economic surveys conducted in Nepal.
Dahal Arjun Kumar, Bhattarai Ganesh, Budhathoki Prem Bahadur, Adhikari Gyan Mani   +3 more
doaj   +1 more source

Female in The Boardroom and Firm Performance: An Insight of Indonesia’s Firms

Revista Finanzas y Política Económica
The purpose of this research is to determine the impact of female board members on firm performance. This study employed a purposive sampling technique with a research sample comprised of 264 non-financial companies listed on the Indonesia Stock ...
Gatot Nazir Ahmad, Dicky Iranto , Edo Siregar , Dianta A. Sebayang   +3 more
doaj   +1 more source

MENGATASI PENCILAN PADA PEMODELAN REGRESI LINEAR BERGANDA DENGAN METODE REGRESI ROBUST PENAKSIR LMS

Barekeng, 2019
Ordinary Least Squares (OLS) is frequent used method for estimating parameters. OLS estimator is not a robust regression procedure for the presence of outliers, so the estimate becomes inappropriate.
Farida Daniel
doaj   +1 more source